EP 3411716 A1 20181212 - COMBINED BIOMARKER MEASUREMENT OF FIBROSIS
Title (en)
COMBINED BIOMARKER MEASUREMENT OF FIBROSIS
Title (de)
KOMBINIERTE BIOMARKERMESSUNG VON FIBROSE
Title (fr)
MESURE DE LA FIBROSE PAR UNE ASSOCIATION DE BIOMARQUEURS
Publication
Application
Priority
- US 201615014241 A 20160203
- EP 2017052271 W 20170202
Abstract (en)
[origin: WO2017134172A1] Provided herein is a sandwich immunoassay for detecting cross-linked PIIINP that has at least two strands of PIIINP joined together by inter-strand cross-linking each having a C-terminal neo-epitope of PIIINP that is generated by N-protease cleavage of intact type III procollagen. A biological sample having the cross-linked PIIINP is contacted with a first surface-bound monoclonal antibody and then by a second monoclonal antibody, both specifically reactive with a neoepitope in the C-terminal sequence of PIIINP, and then binding of the second monoclonal antibody is determined. Also provided is a method for evaluating the efficacy of an antagonist drug targeting lysyl oxidases via the immunoassay and a kit containing a solid support binding the first monoclonal antibody and containing the second monoclonal antibody.
IPC 8 full level
G01N 33/577 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP KR)
G01N 33/577 (2013.01 - EP KR); G01N 33/581 (2013.01 - KR); G01N 33/6887 (2013.01 - EP KR); G01N 2333/78 (2013.01 - EP KR); G01N 2500/00 (2013.01 - KR); G01N 2800/085 (2013.01 - EP KR); G01N 2800/52 (2013.01 - EP KR); G01N 2800/7052 (2013.01 - EP KR); Y02A 50/30 (2018.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017134172 A1 20170810; CA 3009445 A1 20170810; CA 3009445 C 20240319; CN 108431606 A 20180821; CN 108431606 B 20220405; EP 3411716 A1 20181212; JP 2019510210 A 20190411; JP 7094219 B2 20220701; KR 102668479 B1 20240522; KR 20180104648 A 20180921
DOCDB simple family (application)
EP 2017052271 W 20170202; CA 3009445 A 20170202; CN 201780005886 A 20170202; EP 17703944 A 20170202; JP 2018540058 A 20170202; KR 20187023013 A 20170202