EP 3414329 A1 20181219 - RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF
Title (en)
RNA/DNA HYBRID NANOPARTICLES MODIFIED WITH SINGLE STRANDED RNA TOEHOLDS AND USES THEREOF
Title (de)
HYBRIDE RNS/DNS-NANOPARTIKEL MIT EINZELSTRÄNGIGEN RNS-TOEHOLDS UND VERWENDUNGEN DAVON
Title (fr)
NANOPARTICULES HYBRIDES D'ARN/ADN MODIFIÉES AVEC DES ANCRAGES D'ARN SIMPLE BRIN ET LEURS UTILISATIONS
Publication
Application
Priority
- US 201662294848 P 20160212
- US 2017017661 W 20170213
Abstract (en)
[origin: WO2017139758A1] The invention discloses the use of single- stranded RNA toeholds of different lengths to promote the re-association of various RNA-DNA hybrids, which results in activation of multiple split functionalities inside human cells. Previously designed RNA/DNA nanoparticles employed single- stranded DNA toeholds to initiate re-association. The use of RNA toeholds is advantageous because of the simpler design rules, the shorter toeholds, and the smaller size of the resulting nanoparticles compared to the same hybrid nanoparticles with single-stranded DNA toeholds. Moreover, the co-transcriptional assemblies result in higher yields for hybrid nanoparticles with ssRNA toeholds.
IPC 8 full level
C12N 15/113 (2010.01); A61K 47/55 (2017.01); B82Y 5/00 (2011.01); C12N 15/87 (2006.01)
CPC (source: EP US)
A61K 47/555 (2017.07 - EP US); A61K 47/6925 (2017.07 - EP US); A61K 47/6929 (2017.07 - US); C12N 15/111 (2013.01 - EP US); C12N 15/113 (2013.01 - US); C12N 15/87 (2013.01 - EP US); B82Y 5/00 (2013.01 - EP US); C12N 2310/14 (2013.01 - EP US); C12N 2310/351 (2013.01 - US); C12N 2310/50 (2013.01 - US); C12N 2320/50 (2013.01 - EP US); C12N 2330/50 (2013.01 - EP US)
Citation (search report)
See references of WO 2017139758A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017139758 A1 20170817; EP 3414329 A1 20181219; US 2019192687 A1 20190627; US 2021162066 A1 20210603
DOCDB simple family (application)
US 2017017661 W 20170213; EP 17706653 A 20170213; US 201716076878 A 20170213; US 202017102786 A 20201124