EP 3416978 A4 20191106 - MULTIVALENT HIV VACCINE BOOST COMPOSITIONS AND METHODS OF USE
Title (en)
MULTIVALENT HIV VACCINE BOOST COMPOSITIONS AND METHODS OF USE
Title (de)
MULTIVALENTE HIV-IMPFSTOFF-BOOSTZUSAMMENSETZUNG UND VERFAHREN ZUR VERWENDUNG
Title (fr)
COMPOSITIONS MULTIVALENTES VACCINALES DE RAPPEL CONTRE LE VIH ET LEURS PROCÉDÉS D'UTILISATION
Publication
Application
Priority
- US 201662295779 P 20160216
- US 2017018103 W 20170216
Abstract (en)
[origin: WO2017143016A1] Compositions and methods of use are provided to boost a primed immune response to HIV. More specifically, the present invention relates to vaccine compositions comprising an HIV- protein boost or an MVA-expressed Env protein and methods of use. Exemplary HIV proteins for protein boosts include proteins such as gp120 proteins B.63521Δ11mutC and full-length single chain (FLSC), which has been modified to stabilize a CD4-induced Env structure. Exemplary MVAs expressing secreted Methods of administration and dosing regimens are also provided.
IPC 8 full level
A61K 39/21 (2006.01); C07K 14/155 (2006.01); C07K 14/16 (2006.01); C12N 7/04 (2006.01); C12N 15/63 (2006.01); C12N 15/86 (2006.01)
CPC (source: EP US)
A61K 39/12 (2013.01 - EP); A61K 39/21 (2013.01 - US); C07K 14/005 (2013.01 - EP); C07K 14/161 (2013.01 - US); C07K 14/162 (2013.01 - US); C07K 14/163 (2013.01 - US); C12N 15/86 (2013.01 - US); C12N 15/8636 (2013.01 - US); A61K 2039/5258 (2013.01 - EP); A61K 2039/545 (2013.01 - EP); C12N 2710/24143 (2013.01 - EP US); C12N 2740/16023 (2013.01 - US); C12N 2740/16134 (2013.01 - EP US); C12N 2740/16234 (2013.01 - US); C12N 2740/16334 (2013.01 - US)
Citation (search report)
- [XP] WO 2016049287 A1 20160331 - BETH ISRAEL HOSPITAL [US], et al
- [XD] SUZAN L. BUGE ET AL: "Gp120-Alum Boosting of a Gag-Pol-Env DNA/MVA AIDS Vaccine: Poorer Control of a Pathogenic Viral Challenge", AIDS RESEARCH AND HUMAN RETROVIRUSES., vol. 19, no. 10, 1 October 2003 (2003-10-01), US, pages 891 - 900, XP055625401, ISSN: 0889-2229, DOI: 10.1089/088922203322493067
- [AD] SMITA S. IYER ET AL: "Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5 + and CXCR5 - CD4 T Cell Responses in Rhesus Macaques", THE JOURNAL OF IMMUNOLOGY, vol. 195, no. 3, 26 June 2015 (2015-06-26), US, pages 994 - 1005, XP055625382, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1500083
- [A] LETVIN N ET AL: "Potent, protective anti-HIV immune responses generated by bimodal HIV envelope DNA plus protein vaccination", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES (PNAS), US, vol. 94, 19 August 1997 (1997-08-19), pages 9378 - 9383, XP002097492, ISSN: 0027-8424, DOI: 10.1073/PNAS.94.17.9378
- [T] XIAOYING SHEN ET AL: "HIV gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine", JOURNAL OF VIROLOGY., vol. 91, no. 24, 15 December 2017 (2017-12-15), US, XP055625363, ISSN: 0022-538X, DOI: 10.1128/JVI.01077-17
- See references of WO 2017143016A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017143016 A1 20170824; AU 2017221379 A1 20180816; CA 3014419 A1 20170824; EP 3416978 A1 20181226; EP 3416978 A4 20191106; US 11098086 B2 20210824; US 11897919 B2 20240213; US 2019382453 A1 20191219; US 2022112248 A1 20220414
DOCDB simple family (application)
US 2017018103 W 20170216; AU 2017221379 A 20170216; CA 3014419 A 20170216; EP 17753803 A 20170216; US 201716077215 A 20170216; US 202117409574 A 20210823