EP 3420077 A1 20190102 - VIRAL AND ONCOVIRAL NUCLEASE TREATMENT
Title (en)
VIRAL AND ONCOVIRAL NUCLEASE TREATMENT
Title (de)
VIRALE UND ONKOVIRALE NUKLEASEBEHANDLUNG
Title (fr)
TRAITEMENT AU MOYEN D'UNE NUCLÉASE VIRALE ET ONCOVIRALE
Publication
Application
Priority
- US 201662299792 P 20160225
- US 201662299839 P 20160225
- US 2017019390 W 20170224
Abstract (en)
[origin: WO2017147446A1] Compositions and methods for treating infection-associated cancer include the use of a nuclease that cuts nucleic acid of an oncovirus in combination with an adjunct chemo therapeutic that treats cancerous cells. For example, a Cas9 endonuclease and a guide RNA that matches a target in a viral genome without having any corresponding match in the human genome can be delivered along with an anti-apoptotic inhibitor. Embodiments treat a viral infection and use a nuclease and an inhibitor that prevents DNA repair, such as a CRISPR-associated nuclease and a small molecule that inhibits an enzyme of a repair pathway. Under guidance of a targeting sequence, the nuclease cuts viral nucleic acid without cutting the patient's genome. The cut ends of the viral nucleic acid are not repaired because the inhibitor prevents a repair mechanism.
IPC 8 full level
C12N 9/22 (2006.01); A61K 9/127 (2006.01); A61P 31/12 (2006.01); C07H 21/04 (2006.01); C12N 15/09 (2006.01); C12N 15/113 (2010.01); C12N 15/12 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
A61P 31/12 (2017.12); C12N 9/22 (2013.01); C12N 15/09 (2013.01); C12N 15/102 (2013.01); C12N 15/1131 (2013.01); G01N 33/5308 (2013.01); G01N 33/569 (2013.01); G01N 33/574 (2013.01); C12N 2310/20 (2017.04); C12N 2320/30 (2013.01); C12N 2320/32 (2013.01); G01N 2333/922 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017147446 A1 20170831; AU 2017223964 A1 20180906; CA 3015353 A1 20170831; EP 3420077 A1 20190102; EP 3420077 A4 20191225
DOCDB simple family (application)
US 2017019390 W 20170224; AU 2017223964 A 20170224; CA 3015353 A 20170224; EP 17757316 A 20170224