Global Patent Index - EP 3420080 B1

EP 3420080 B1 20190821 - METHODS FOR MODULATING DNA REPAIR OUTCOMES

Title (en)

METHODS FOR MODULATING DNA REPAIR OUTCOMES

Title (de)

VERFAHREN ZUR MODULATION VON DNA-REPARATURERGEBNISSEN

Title (fr)

MÉTHODES DE MODULATION DE RÉSULTATS DE RÉPARATION D'ADN

Publication

EP 3420080 B1 20190821 (EN)

Application

EP 17711029 A 20170221

Priority

  • US 201662298129 P 20160222
  • US 201662344876 P 20160602
  • US 2017018679 W 20170221

Abstract (en)

[origin: WO2017147056A1] Methods for gene editing and predicting non-random editing events are described. The methods use Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) systems to characterize and manipulate DNA repair outcomes at Cas-initiated double-strand breaks (DSBs) to anticipate functional outcomes.

IPC 8 full level

C12N 15/10 (2006.01); C12N 15/11 (2006.01); C12N 15/90 (2006.01)

CPC (source: EP US)

C12N 15/102 (2013.01 - EP US); C12N 15/11 (2013.01 - US); C12N 15/90 (2013.01 - EP US); C12N 15/902 (2013.01 - EP US); C12N 15/907 (2013.01 - US); C12N 2310/20 (2017.04 - US); C12N 2800/80 (2013.01 - US)

Citation (examination)

  • WO 2015021353 A1 20150212 - HARVARD COLLEGE [US]
  • WO 2014150624 A1 20140925 - CARIBOU BIOSCIENCES INC [US]
  • WO 2016033246 A1 20160303 - CARIBOU BIOSCIENCES INC [US]
  • WO 2016186946 A1 20161124 - PIONEER HI BRED INT [US]
  • WO 2015021353 A1 20150212 - HARVARD COLLEGE [US]
  • WO 2014150624 A1 20140925 - CARIBOU BIOSCIENCES INC [US]
  • WO 2016033246 A1 20160303 - CARIBOU BIOSCIENCES INC [US]
  • WO 2016186946 A1 20161124 - PIONEER HI BRED INT [US]
  • BRINER ALEXANDRA E ET AL: "Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality", 16 October 2014, MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, PAGE(S) 333 - 339, ISSN: 1097-2765, XP029084886
  • FONFARA ET AL.: "Phylogeny of Cas9 Determines Functional Exchangeability of Dual-RNA and Cas9 among Orthologous Type II CRISPR/Cas Systems", NUCLEIC ACIDS RESEARCH, vol. 42, 2014, pages 2577 - 2590, XP055399937
  • M. JINEK ET AL: "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, vol. 337, no. 6096, 17 August 2012 (2012-08-17), US, pages 816 - 821, XP055299674, ISSN: 0036-8075, DOI: 10.1126/science.1225829
  • VAN OVERBEEK MEGAN ET AL: "DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.", MOLECULAR CELL 18 08 2016, vol. 63, no. 4, 4 August 2016 (2016-08-04), pages 633 - 646, XP029690136, ISSN: 1097-4164 & MEGAN VAN OVERBEEK ET AL: "Molecular Cell, Volume 63 Supplemental Information DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks", 4 August 2016 (2016-08-04), XP055580643, Retrieved from the Internet <URL:https://ars.els-cdn.com/content/image/1-s2.0-S1097276516303252-mmc1.pdf> [retrieved on 20190412]
  • CAROLIN ANDERS ET AL: "Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease", NATURE, vol. 513, no. 7519, 27 July 2014 (2014-07-27), London, pages 569 - 573, XP055240929, ISSN: 0028-0836, DOI: 10.1038/nature13579
  • G. GASIUNAS ET AL: "Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 109, no. 39, 25 September 2012 (2012-09-25), US, pages E2579 - E2586, XP055569955, ISSN: 0027-8424, DOI: 10.1073/pnas.1208507109
  • F. JIANG ET AL: "Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage", SCIENCE, vol. 351, no. 6275, 14 January 2016 (2016-01-14), US, pages 867 - 871, XP055519565, ISSN: 0036-8075, DOI: 10.1126/science.aad8282
  • HIROSHI NISHIMASU ET AL: "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA", CELL, vol. 156, no. 5, 1 February 2014 (2014-02-01), AMSTERDAM, NL, pages 935, XP055423859, ISSN: 0092-8674, DOI: 10.1016/j.cell.2014.02.001
  • SAMUEL H. STERNBERG ET AL: "Conformational control of DNA target cleavage by CRISPR-Cas9", NATURE, vol. 527, no. 7576, 28 October 2015 (2015-10-28), London, pages 110 - 113, XP055535411, ISSN: 0028-0836, DOI: 10.1038/nature15544
  • FELICITY ALLEN ET AL: "Predicting the mutations generated by repair of Cas9-induced double-strand breaks", NATURE BIOTECHNOLOGY, vol. 37, no. 1, 27 November 2018 (2018-11-27), New York, pages 64 - 72, XP055580704, ISSN: 1087-0156, DOI: 10.1038/nbt.4317 & FELICITY ALLEN ET AL: "Supporting Information: Predicting the mutations generated by repair of Cas9-induced double-strand breaks", NATURE BIOTECHNOLOGY, vol. 37, no. 1, 27 November 2018 (2018-11-27), New York, pages 1 - 37, XP055580718, ISSN: 1087-0156, DOI: 10.1038/nbt.4317
  • BRINER ALEXANDRA E ET AL: "Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality", 16 October 2014, MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, PAGE(S) 333 - 339, ISSN: 1097-2765, XP029084886
  • FONFARA ET AL.: "Phylogeny of Cas9 Determines Functional Exchangeability of Dual-RNA and Cas9 among Orthologous Type II CRISPR/Cas Systems", NUCLEIC ACIDS RESEARCH, vol. 42, 2014, pages 2577 - 2590, XP055399937
  • M. JINEK ET AL: "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, vol. 337, no. 6096, 17 August 2012 (2012-08-17), US, pages 816 - 821, XP055299674, ISSN: 0036-8075, DOI: 10.1126/science.1225829
  • VAN OVERBEEK MEGAN ET AL: "DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks.", MOLECULAR CELL 18 08 2016, vol. 63, no. 4, 4 August 2016 (2016-08-04), pages 633 - 646, XP029690136, ISSN: 1097-4164 & MEGAN VAN OVERBEEK ET AL: "Molecular Cell, Volume 63 Supplemental Information DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks", 4 August 2016 (2016-08-04), XP055580643, Retrieved from the Internet <URL:https://ars.els-cdn.com/content/image/1-s2.0-S1097276516303252-mmc1.pdf> [retrieved on 20190412]
  • CAROLIN ANDERS ET AL: "Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease", NATURE, vol. 513, no. 7519, 27 July 2014 (2014-07-27), London, pages 569 - 573, XP055240929, ISSN: 0028-0836, DOI: 10.1038/nature13579
  • G. GASIUNAS ET AL: "Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 109, no. 39, 25 September 2012 (2012-09-25), US, pages E2579 - E2586, XP055569955, ISSN: 0027-8424, DOI: 10.1073/pnas.1208507109
  • F. JIANG ET AL: "Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage", SCIENCE, vol. 351, no. 6275, 14 January 2016 (2016-01-14), US, pages 867 - 871, XP055519565, ISSN: 0036-8075, DOI: 10.1126/science.aad8282
  • HIROSHI NISHIMASU ET AL: "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA", CELL, vol. 156, no. 5, 1 February 2014 (2014-02-01), AMSTERDAM, NL, pages 935, XP055423859, ISSN: 0092-8674, DOI: 10.1016/j.cell.2014.02.001
  • SAMUEL H. STERNBERG ET AL: "Conformational control of DNA target cleavage by CRISPR-Cas9", NATURE, vol. 527, no. 7576, 28 October 2015 (2015-10-28), London, pages 110 - 113, XP055535411, ISSN: 0028-0836, DOI: 10.1038/nature15544
  • FELICITY ALLEN ET AL: "Predicting the mutations generated by repair of Cas9-induced double-strand breaks", NATURE BIOTECHNOLOGY, vol. 37, no. 1, 27 November 2018 (2018-11-27), New York, pages 64 - 72, XP055580704, ISSN: 1087-0156, DOI: 10.1038/nbt.4317 & FELICITY ALLEN ET AL: "Supporting Information: Predicting the mutations generated by repair of Cas9-induced double-strand breaks", NATURE BIOTECHNOLOGY, vol. 37, no. 1, 27 November 2018 (2018-11-27), New York, pages 1 - 37, XP055580718, ISSN: 1087-0156, DOI: 10.1038/nbt.4317

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2017147056 A1 20170831; DK 3420080 T3 20191125; DK 3653709 T3 20210308; EP 3420080 A1 20190102; EP 3420080 B1 20190821; EP 3653709 A1 20200520; EP 3653709 B1 20201209; ES 2754785 T3 20200420; ES 2847252 T3 20210802; US 11155814 B2 20211026; US 2019055549 A1 20190221

DOCDB simple family (application)

US 2017018679 W 20170221; DK 17711029 T 20170221; DK 19192206 T 20170221; EP 17711029 A 20170221; EP 19192206 A 20170221; ES 17711029 T 20170221; ES 19192206 T 20170221; US 201716078014 A 20170221