EP 3423480 A1 20190109 - L-ASPARAGINASE VARIANTS AND FUSION PROTEINS WITH REDUCED L-GLUTAMINASE ACTIVITY AND ENHANCED STABILITY
Title (en)
L-ASPARAGINASE VARIANTS AND FUSION PROTEINS WITH REDUCED L-GLUTAMINASE ACTIVITY AND ENHANCED STABILITY
Title (de)
L-ASPARAGINASE-VARIANTEN UND FUSIONSPROTEINE MIT VERMINDERTER L-GLUTAMINASE-AKTIVITÄT UND ERHÖHTER STABILITÄT
Title (fr)
VARIANTS ET PROTÉINES DE FUSION DE L-ASPARAGINASE AYANT UNE ACTIVITÉ L-GLUTAMINASE RÉDUITE ET UNE STABILITÉ AMÉLIORÉE
Publication
Application
Priority
- US 201662301806 P 20160301
- US 201662347376 P 20160608
- US 201762446026 P 20170113
- US 2017020090 W 20170301
Abstract (en)
[origin: WO2017151707A1] Variant Erwinia chrysanthemi L-asparaginases with reduced L-glutaminase activity and enhanced in vivo circulation are described as are fusion proteins containing an L-asparaginase and three tandem soluble domains of TRAIL for use in the treatment of cancers such as acute lymphoblastic leukemia and acute myeloid leukemia.
IPC 8 full level
A61K 38/50 (2006.01); C07K 14/52 (2006.01); C12N 9/82 (2006.01)
CPC (source: EP US)
A61K 38/50 (2013.01 - EP US); A61K 47/65 (2017.07 - US); A61K 47/67 (2017.07 - US); A61K 47/6815 (2017.07 - US); A61P 35/00 (2017.12 - EP US); C07K 14/52 (2013.01 - EP US); C12N 1/205 (2021.05 - US); C12N 9/82 (2013.01 - EP US); C12N 15/52 (2013.01 - EP US); C12Y 305/01001 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); C07K 2319/35 (2013.01 - EP US); C07K 2319/74 (2013.01 - EP US); C12R 2001/18 (2021.05 - US); Y02A 50/30 (2017.12 - EP US)
Citation (search report)
See references of WO 2017151707A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017151707 A1 20170908; CA 3054286 A1 20170908; CN 109153711 A 20190104; CN 109153711 B 20220426; EP 3423480 A1 20190109; JP 2019509041 A 20190404; JP 7091248 B2 20220627; US 10821160 B2 20201103; US 2019070274 A1 20190307
DOCDB simple family (application)
US 2017020090 W 20170301; CA 3054286 A 20170301; CN 201780014261 A 20170301; EP 17711054 A 20170301; JP 2018545838 A 20170301; US 201716080435 A 20170301