EP 3424908 A1 20190109 - PROCESS FOR PREPARATION OF LEVOSIMENDAN
Title (en)
PROCESS FOR PREPARATION OF LEVOSIMENDAN
Title (de)
VERFAHREN ZUR HERSTELLUNG VON LEVOSIMENDAN
Title (fr)
PROCÉDÉ DE PRÉPARATION DE LEVOSIMENDAN
Publication
Application
Priority
IN 201721023959 A 20170707
Abstract (en)
The present invention discloses a process for preparation of levosimendan. More particularly, the present invention discloses novel process for preparation of (-)-6-(4-aminophenyl)-5-methylpyridazin-3-(2H)-one from racemic 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone using (R)-2-acetamido-3-mercaptopropanoic acid and further converting the (-)-6-(4-aminophenyl)-5-methylpyridazin-3-(2H)-one into levosimendan. The invention further relates to a novel intermediate, (R)-2-acetamido-3-mercaptopropionate salt of (-)-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3-(2H)-pyridazinone of formula (1a) and novel crystalline polymorphic form II of levosimendan.
IPC 8 full level
C07D 237/04 (2006.01); A61K 31/50 (2006.01)
CPC (source: EP)
C07D 237/04 (2013.01)
Citation (applicant)
- GB 2228004 A 19900815 - ORION YHTYMAE OY [FI]
- US 5569657 A 19961029 - NORE PENTTI [FI], et al
- EP 0208518 A2 19870114 - SMITH KLINE FRENCH LAB [GB]
- US 6180789 B1 20010130 - TIMMERBACKA MIKA [FI], et al
- US 9000158 B2 20150407 - RAO DHARMARAJ RAMACHANDRA [IN], et al
- WIKBERG TL; KORKOLAINEN T; KARLSSON M: "Orion-Farmos, Orion Research", CHIRALITY, vol. 8, no. 7, 1996, pages 511 - 517
Citation (search report)
- [ID] WO 9735841 A2 19971002 - ORION YHTYMAE OY [FI], et al
- [ID] WO 2011007123 A1 20110120 - CIPLA LTD [IN], et al
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
EP 17195069 A 20171005