EP 3426677 B1 20231206 - USE OF PNEUMOLYSIN PEPTIDES AS ANTAGONISTS AGAINST TOLL-LIKE RECEPTOR 4 AND METHODS OF TREATING TOLL-LIKE RECEPTOR 4 RELATED DISEASES
Title (en)
USE OF PNEUMOLYSIN PEPTIDES AS ANTAGONISTS AGAINST TOLL-LIKE RECEPTOR 4 AND METHODS OF TREATING TOLL-LIKE RECEPTOR 4 RELATED DISEASES
Title (de)
VERWENDUNG VON PNEUMOLYSINPEPTIDEN ALS ANTAGONISTEN GEGEN DEN TOLL-LIKE-REZEPTOR 4 UND VERFAHREN ZUR BEHANDLUNG VON KRANKHEITEN IM ZUSAMMENHANG MIT TOLL-LIKE-REZEPTOR 4
Title (fr)
UTILISATION DE PEPTIDES DE PNEUMOLYSINE EN TANT QU'ANTAGONISTES CONTRE LE RÉCEPTEUR 4 DE TYPE TOLL ET MÉTHODES DE TRAITEMENT DES MALADIES LIÉES AU RÉCEPTEURS 4 DE TYPE TOLL
Publication
Application
Priority
- US 201662305164 P 20160308
- CA 2017050238 W 20170224
Abstract (en)
[origin: US2017260241A1] The present invention relates to treatment of diabetes, toll-like receptor 4 (TLR-4) modulators and methods for using the same. Particularly, the present invention provides an isolated peptide from pneumolysin (PLY peptide) which is effective in treatment of diabetes. In addition, the PLY peptide of the present invention is a TLR-4 antagonist and thus can be used in the treatment of a disease or condition associated with TLR-4 activation. The present invention also provides treatment of diabetes with a TLR-4 antagonist.
IPC 8 full level
C07K 14/315 (2006.01); A61K 35/74 (2015.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61P 3/10 (2006.01); C07K 7/06 (2006.01); C07K 14/705 (2006.01); C12N 15/31 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP KR US)
A61P 3/10 (2017.12 - EP KR US); A61P 9/00 (2017.12 - EP KR); A61P 9/10 (2017.12 - EP); A61P 29/00 (2017.12 - EP US); C07K 14/3156 (2013.01 - EP KR US); C07K 14/705 (2013.01 - EP KR US); C12N 15/62 (2013.01 - KR); A61K 38/00 (2013.01 - EP KR US); C07K 2319/00 (2013.01 - KR)
Citation (examination)
A. SRIVASTAVA ET AL: "The Apoptotic Response to Pneumolysin Is Toll-Like Receptor 4 Dependent and Protects against Pneumococcal Disease", INFECTION AND IMMUNITY, vol. 73, no. 10, 1 October 2005 (2005-10-01), US, pages 6479 - 6487, XP055423835, ISSN: 0019-9567, DOI: 10.1128/IAI.73.10.6479-6487.2005
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
US 10287328 B2 20190514; US 2017260241 A1 20170914; AU 2017231108 A1 20180927; AU 2017231108 B2 20210617; CA 3016815 A1 20170914; CN 109071614 A 20181221; CN 109071614 B 20220906; EP 3426677 A1 20190116; EP 3426677 A4 20191120; EP 3426677 B1 20231206; EP 3426677 C0 20231206; KR 20180120738 A 20181106; SG 11201807729Y A 20181030; TW 201739759 A 20171116; TW I769150 B 20220701; US 2019359658 A1 20191128; WO 2017152270 A1 20170914
DOCDB simple family (application)
US 201715441390 A 20170224; AU 2017231108 A 20170224; CA 2017050238 W 20170224; CA 3016815 A 20170224; CN 201780016084 A 20170224; EP 17762367 A 20170224; KR 20187028702 A 20170224; SG 11201807729Y A 20170224; TW 106106567 A 20170224; US 201916356511 A 20190318