Global Patent Index - EP 3430060 A4

EP 3430060 A4 20191127 - CONJUGATES ENHANCING TOTAL CELLULAR ACCUMULATION

Title (en)

CONJUGATES ENHANCING TOTAL CELLULAR ACCUMULATION

Title (de)

KONJUGATE ZUR VERBESSERUNG DER GESAMTEN ZELLULÄREN AKKUMULATION

Title (fr)

CONJUGUÉS FAVORISANT L'ACCUMULATION CELLULAIRE TOTALE

Publication

EP 3430060 A4 20191127 (EN)

Application

EP 17765615 A 20170315

Priority

  • US 201662308457 P 20160315
  • CA 2017050337 W 20170315

Abstract (en)

[origin: WO2017156630A1] The present description relates to a conjugated compound comprising cholic acid (ChAc) or a variant thereof, the ChAc conjugated to a non-cell penetrating peptide comprising a nuclear localization sequence (NLS) conjugated to a compound of interest.

IPC 8 full level

A61K 47/54 (2017.01); A61K 47/64 (2017.01); A61K 51/08 (2006.01); C07H 21/00 (2006.01); C07K 7/08 (2006.01); C07K 14/025 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 15/113 (2010.01); G01N 33/574 (2006.01)

CPC (source: EP IL US)

A61K 47/542 (2017.08 - EP IL US); A61K 47/64 (2017.08 - EP IL US); A61K 47/6803 (2017.08 - US); A61K 47/68033 (2023.08 - EP IL); A61K 47/6845 (2017.08 - EP IL US); A61K 47/6855 (2017.08 - EP IL US); A61P 35/00 (2018.01 - EP IL); A61P 35/02 (2018.01 - EP IL); C07J 9/005 (2013.01 - IL); C07K 16/3061 (2013.01 - EP IL US); C07K 16/32 (2013.01 - EP IL US); C12N 15/111 (2013.01 - EP IL US); C07J 9/005 (2013.01 - EP US); C07K 2317/77 (2013.01 - EP IL US); C07K 2319/09 (2013.01 - EP IL US); C07K 2319/55 (2013.01 - EP IL US); C12N 2310/11 (2013.01 - EP IL US); C12N 2310/14 (2013.01 - EP IL US); C12N 2310/3513 (2013.01 - EP IL US); C12N 2310/3515 (2013.01 - EP IL US); C12N 2320/32 (2013.01 - EP IL US); C12N 2710/22022 (2013.01 - EP IL US)

Citation (search report)

  • [Y] J. V. LEYTON ET AL: "Auger Electron Radioimmunotherapeutic Agent Specific for the CD123+/CD131- Phenotype of the Leukemia Stem Cell Population", THE JOURNAL OF NUCLEAR MEDICINE, vol. 52, no. 9, 4 August 2011 (2011-08-04), US, pages 1465 - 1473, XP055424244, ISSN: 0161-5505, DOI: 10.2967/jnumed.111.087668
  • [Y] SWAAN P W ET AL: "Enhanced Transepithelial Transport of Peptides by Conjugation to Cholic Acid", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 8, 1 January 1997 (1997-01-01), pages 520 - 525, XP002391295, ISSN: 1043-1802, DOI: 10.1021/BC970076T
  • [A] MOUNA RAOUANE ET AL: "Lipid Conjugated Oligonucleotides: A Useful Strategy for Delivery", BIOCONJUGATE CHEMISTRY, vol. 23, no. 6, 20 June 2012 (2012-06-20), pages 1091 - 1104, XP055143861, ISSN: 1043-1802, DOI: 10.1021/bc200422w
  • [A] KIM BIEONG-KIL ET AL: "Homodimeric SV40 NLS peptide formed by disulfide bond as enhancer for gene delivery", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 17, 20 July 2012 (2012-07-20), pages 5415 - 5418, XP028934586, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2012.07.051
  • [A] MANOHARAN M ET AL: "Cholic acid-oligonucleotide conjugates for antisense applications", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 4, no. 8, 21 April 1994 (1994-04-21), pages 1053 - 1060, XP026615485, ISSN: 0960-894X, [retrieved on 19940421], DOI: 10.1016/S0960-894X(01)80680-6
  • [XP] SIMON BEAUDOIN ET AL: "ChAcNLS, a Novel Modification to Antibody-Conjugates Permitting Target Cell-Specific Endosomal Escape, Localization to the Nucleus, and Enhanced Total Intracellular Accumulation", MOLECULAR PHARMACEUTICS, vol. 13, no. 6, 6 June 2016 (2016-06-06), US, pages 1915 - 1926, XP055403560, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.6b00075
  • See also references of WO 2017156630A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2017156630 A1 20170921; AU 2017233725 A1 20181025; AU 2017233725 B2 20231019; CA 3017950 A1 20170921; EP 3430060 A1 20190123; EP 3430060 A4 20191127; IL 261765 A 20181031; IL 261765 B 20220801; JP 2019512545 A 20190516; JP 7126956 B2 20220829; US 11352437 B2 20220607; US 2019077879 A1 20190314

DOCDB simple family (application)

CA 2017050337 W 20170315; AU 2017233725 A 20170315; CA 3017950 A 20170315; EP 17765615 A 20170315; IL 26176518 A 20180913; JP 2018568469 A 20170315; US 201716085141 A 20170315