EP 3442947 B1 20230607 - AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS

Title (en)

AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS

Title (de)

AMINE-SUBSTITUIERTE ARYL- ODER HETEROARYL-VERBINDUNGEN ALS EHMT1 AND EHMT2 INHIBITOREN

Title (fr)

DÉRIVÉS D'ARYL OU HETEROARYL SUBSTITUÉS PAR UNE AMINE COMME INHIBITEURS DE EHMT1 ET EHMT2

Publication

EP 3442947 B1 20230607 (EN)

Application

EP 17720921 A 20170417

Priority

US 201662323602 P 20160415
US 201662348837 P 20160610
US 201662402997 P 20160930
US 2017027918 W 20170417

Abstract (en)

[origin: WO2017181177A1] The present disclosure relates to amine-substituted aryl or heteroaryl compounds. The present disclosure also relates to pharmaceutical compositions containing these compounds and methods of treating a disorder (e.g., sickle cell anemia) via inhibition of a methyltransferase enzyme selected from EHMT1 and EHMT2, by administering an amine-substituted aryl or heteroaryl compound disclosed herein or a pharmaceutical composition thereof to subjects in need thereof. The present disclosure also relates to the use of such compounds for research or other non-therapeutic purposes.

IPC 8 full level

C07D 231/38 (2006.01); A61K 31/44 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61P 7/06 (2006.01); A61P 35/02 (2006.01); C07D 239/48 (2006.01); C07D 401/12 (2006.01)

CPC (source: EP IL KR US)

A61K 31/506 (2013.01 - IL KR); A61P 7/06 (2018.01 - EP IL KR); A61P 35/02 (2018.01 - EP IL KR); A61P 43/00 (2018.01 - EP IL); C07D 213/74 (2013.01 - EP IL US); C07D 215/38 (2013.01 - EP IL US); C07D 231/38 (2013.01 - EP IL US); C07D 239/48 (2013.01 - EP IL KR US); C07D 239/49 (2013.01 - EP IL US); C07D 401/12 (2013.01 - EP IL KR US); C07D 401/14 (2013.01 - EP IL KR US); C07D 403/12 (2013.01 - EP IL KR US); C07D 403/14 (2013.01 - EP IL US); C07D 405/12 (2013.01 - EP IL US); C07D 405/14 (2013.01 - EP IL KR US); C07D 409/14 (2013.01 - EP IL US); C07D 413/12 (2013.01 - EP IL US); C07D 413/14 (2013.01 - EP IL US); C07D 471/04 (2013.01 - EP IL KR US); C07D 473/32 (2013.01 - EP IL US); C07D 487/04 (2013.01 - EP IL US); C07D 491/044 (2013.01 - EP IL US); C07D 498/04 (2013.01 - EP IL US)

Citation (examination)

WO 2010129802 A1 20101111 - PORTOLA PHARM INC [US], et al
US 2011230478 A1 20110922 - GREUL JOERG NICO [DE], et al
US 2007021446 A1 20070125 - EHLERT JAN [DE], et al
WO 03032994 A2 20030424 - BOEHRINGER INGELHEIM PHARMA [DE], et al
DAS ET AL: "Dithiocarbamate and CuO promoted one-pot synthesis of 2-(N-substituted)-aminobenzimidazoles and related heterocycles", TETRAHEDRON LETTERS, ELSEVIER LTD, AMSTERDAM, NL, vol. 49, no. 6, 8 December 2007 (2007-12-08), pages 992 - 995, XP022417901, ISSN: 0040-4039, DOI: 10.1016/J.TETLET.2007.12.022

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

Designated validation state (EPC)

DOCDB simple family (publication)

WO 2017181177 A1 20171019; AU 2017250369 A1 20181011; AU 2021245168 A1 20211104; AU 2021245168 B2 20231026; AU 2024200464 A1 20240215; BR 112018071093 A2 20190129; CA 3021062 A1 20171019; CL 2018002928 A1 20190201; CL 2019000815 A1 20190816; CN 109153650 A 20190104; CO 2018012181 A2 20190820; DK 3442947 T3 20230904; EP 3442947 A1 20190220; EP 3442947 B1 20230607; ES 2953512 T3 20231114; FI 3442947 T3 20230824; HU E064145 T2 20240328; IL 262140 A 20181129; IL 281319 A 20210429; IL 281319 B1 20231101; IL 281319 B2 20240301; IL 307931 A 20231201; JP 2019513778 A 20190530; JP 2022081606 A 20220531; JP 2024045202 A 20240402; JP 7041070 B2 20220323; JP 7420847 B2 20240123; KR 102571679 B1 20230829; KR 20180133906 A 20181217; KR 20230130747 A 20230912; LT 3442947 T 20230911; MA 44666 A 20190220; MX 2018012622 A 20190829; MX 2022010947 A 20220921; PL 3442947 T3 20231002; PT 3442947 T 20230807; SG 10201913471V A 20200330; SG 11201808799S A 20181129; SI 3442947 T1 20231030; TW 201803854 A 20180201; TW I751155 B 20220101; US 2017355712 A1 20171214; US 2021198277 A1 20210701

DOCDB simple family (application)

US 2017027918 W 20170417; AU 2017250369 A 20170417; AU 2021245168 A 20211007; AU 2024200464 A 20240125; BR 112018071093 A 20170417; CA 3021062 A 20170417; CL 2018002928 A 20181012; CL 2019000815 A 20190328; CN 201780030129 A 20170417; CO 2018012181 A 20181113; DK 17720921 T 20170417; EP 17720921 A 20170417; ES 17720921 T 20170417; FI 17720921 T 20170417; HU E17720921 A 20170417; IL 26214018 A 20181004; IL 28131921 A 20210308; IL 30793123 A 20231022; JP 2018553876 A 20170417; JP 2022036728 A 20220310; JP 2024002232 A 20240111; KR 20187032892 A 20170417; KR 20237028695 A 20170417; LT US2017027918 T 20170417; MA 44666 A 20170417; MX 2018012622 A 20170417; MX 2022010947 A 20181015; PL 17720921 T 20170417; PT 17720921 T 20170417; SG 10201913471V A 20170417; SG 11201808799S A 20170417; SI 201731402 T 20170417; TW 106112816 A 20170417; US 201715601888 A 20170522; US 202017100489 A 20201120