EP 3448852 A4 20190410 - NOVEL HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE BCR-ABL INHIBITORS

Title (en)

NOVEL HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE BCR-ABL INHIBITORS

Title (de)

NEUARTIGE HETEROCYCLISCHE VERBINDUNGEN ALS TYROSINKINASE-BCR-ABL-INHIBITOREN

Title (fr)

NOUVEAUX COMPOSÉS HÉTÉROCYCLIQUES COMME INHIBITEURS DE LA TYROSINE KINASE BCR-ABL

Publication

EP 3448852 A4 20190410 (EN)

Application

EP 17788800 A 20170427

Priority

US 201662391402 P 20160429
CN 2017082243 W 20170427

Abstract (en)

[origin: WO2017186148A1] Disclosed is a compound of Formula (Ⅰ) or a pharmaceutically acceptable salt thereof, wherein the variables are described herein. Also disclosed is a process for the preparation of compounds, their pharmaceutical compositions comprising the same as an active ingredient, methods using said compositions in the treatment of various disorders, and use of the compounds in the manufacture of a medicament in inhibition of the enzymatic activities of ABL1, ABL2 and related chimeric proteins.

IPC 8 full level

C07D 401/14 (2006.01); A61K 31/4439 (2006.01); A61P 35/00 (2006.01); C07D 401/04 (2006.01); C07D 401/10 (2006.01); C07D 403/10 (2006.01); C07D 403/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 487/10 (2006.01); C07D 491/10 (2006.01); C07D 498/08 (2006.01)

CPC (source: EP)

A61K 31/00 (2013.01); A61K 31/4439 (2013.01); A61P 35/00 (2017.12); C07D 213/56 (2013.01); C07D 213/82 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/14 (2013.01); C07D 407/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01)

C-Set (source: EP)

A61K 31/00 + A61K 2300/00

Citation (search report)

[I] WO 2013171642 A1 20131121 - NOVARTIS AG [CH], et al
[A] WO 2013171639 A1 20131121 - NOVARTIS AG [CH], et al
[A] WO 2013171641 A1 20131121 - NOVARTIS AG [CH], et al
See references of WO 2017186148A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2017186148 A1 20171102; CN 109790144 A 20190521; EP 3448852 A1 20190306; EP 3448852 A4 20190410; JP 2019515932 A 20190613

DOCDB simple family (application)

CN 2017082243 W 20170427; CN 201780041283 A 20170427; EP 17788800 A 20170427; JP 2018556929 A 20170427