EP 3452045 A1 20190313 - METHODS OF TREATMENT AND COMBINATION THERAPIES USING GCASE ACTIVATOR HETEROBICYCLIC AND RELATED COMPOUNDS
Title (en)
METHODS OF TREATMENT AND COMBINATION THERAPIES USING GCASE ACTIVATOR HETEROBICYCLIC AND RELATED COMPOUNDS
Title (de)
VERFAHREN ZUR BEHANDLUNG UND KOMBINATIONSBEHANDLUNG UNTER VERWENDUNG VON HETEROBICYCLISCHEN GCASE-AKTIVIERENDEN VERBINDUNGEN UND ANDEREN VERWANDTEN VERBINDUNGEN
Title (fr)
MÉTHODES DE TRAITEMENT ET POLYTHÉRAPIES FAISANT APPEL À DES COMPOSÉS HÉTÉROBICYCLIQUES ACTIVATEURS DE GCASE ET AUTRES COMPOSÉS APPARENTÉS
Publication
Application
Priority
- US 201662331539 P 20160504
- US 2017031044 W 20170504
Abstract (en)
[origin: WO2017192841A1] The invention provides methods of treatment and combination therapies using heterobicyclic and related compounds that activate Gcase, such as in the treatment of endometriosis and Parkinson's disease. An exemplary heterobicyclic compound that activates Gcase is a substituted pyrrolo[1,2-a]pyrimidine compound, such as substituted 2,4-dimethyl-N-phenylpyrrolo[1,2-a]pyrimidine-8-carboxarnide compounds and variants thereof.
IPC 8 full level
A61K 31/519 (2006.01); A61P 15/00 (2006.01); A61P 25/08 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 31/439 (2013.01); A61K 31/513 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01); A61P 15/00 (2017.12); A61P 25/08 (2017.12); A61P 25/16 (2017.12); A61P 25/18 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
See references of WO 2017192841A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
US 2017031044 W 20170504; EP 17793335 A 20170504