EP 3452467 A1 20190313 - METHOD FOR PRODUCING 5-HYDROXYALKYL-SUBSTITUTED 1-PHENYL-1,2,4- TRIAZOLE DERIVATIVES
Title (en)
METHOD FOR PRODUCING 5-HYDROXYALKYL-SUBSTITUTED 1-PHENYL-1,2,4- TRIAZOLE DERIVATIVES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 5-HYDROXYALKYL-SUBSTITUIERTEN 1-PHENYL-1,2,4-TRIAZOLDERIVATIVEN
Title (fr)
PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE 1-PHÉNYL-1,2,4-TRIAZOL 5-HYDROXYALKYL-SUBSTITUÉS
Publication
Application
Priority
- EP 16168163 A 20160503
- EP 16168165 A 20160503
- EP 16168169 A 20160503
- EP 16168166 A 20160503
- EP 16168172 A 20160503
- EP 17160086 A 20170309
- EP 2017060367 W 20170502
Abstract (en)
[origin: WO2017191104A1] The invention relates to a novel and improved method for producing 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole-derivatives of the formula (I), in which R1A and R1B are selected independently of each other from the group comprising hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy, and trifluoromethoxy, to novel precursors for the production, and to the production and to the use of the crystalline modification I of (5-(4-chlorophenyl)-2-({ 1-(3-chlorophenyl)-5-[(1S)-1-hydroxyethyl]-1H-1,2,4-triazole-3-yl}methyl)- 4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazole-3-one.
IPC 8 full level
A61K 31/4196 (2006.01); A61P 9/00 (2006.01); A61P 13/00 (2006.01); C07D 403/06 (2006.01)
CPC (source: CN EP IL KR RU US)
A61K 31/4196 (2013.01 - CN IL KR RU); A61P 9/00 (2017.12 - CN EP IL KR); A61P 13/00 (2017.12 - EP IL KR); A61P 13/12 (2017.12 - CN EP IL); C07D 249/12 (2013.01 - CN EP IL US); C07D 403/06 (2013.01 - EP IL KR RU US); C07B 2200/13 (2013.01 - CN IL KR); Y02P 20/55 (2015.11 - EP)
Citation (search report)
See references of WO 2017191104A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017191104 A1 20171109; AU 2017259872 A1 20181122; AU 2017259872 B2 20210624; AU 2021236502 A1 20211021; BR 112018072528 A2 20190326; CA 3022789 A1 20171109; CL 2018003107 A1 20190222; CN 109071500 A 20181221; CN 109071500 B 20210518; CN 113105403 A 20210713; CO 2018011948 A2 20181122; EP 3452467 A1 20190313; IL 262534 A 20181231; IL 262534 B 20210429; JP 2019514948 A 20190606; JP 2021143193 A 20210924; JP 6921863 B2 20210818; KR 20190003536 A 20190109; MX 2018013336 A 20190509; MX 2020010365 A 20220406; PE 20190202 A1 20190205; RU 2018142264 A 20200603; RU 2018142264 A3 20200819; RU 2742885 C2 20210211; SG 11201809672Y A 20181129; TW 201815782 A 20180501; TW I755393 B 20220221; US 10703742 B2 20200707; US 2019144431 A1 20190516; US 2020299271 A1 20200924; UY 37222 A 20171130
DOCDB simple family (application)
EP 2017060367 W 20170502; AU 2017259872 A 20170502; AU 2021236502 A 20210922; BR 112018072528 A 20170502; CA 3022789 A 20170502; CL 2018003107 A 20181031; CN 201780027607 A 20170502; CN 202110424553 A 20170502; CO 2018011948 A 20181102; EP 17719636 A 20170502; IL 26253418 A 20181023; JP 2018557408 A 20170502; JP 2021098486 A 20210614; KR 20187031568 A 20170502; MX 2018013336 A 20170502; MX 2020010365 A 20170502; PE 2018002254 A 20170502; RU 2018142264 A 20170502; SG 11201809672Y A 20170502; TW 106114435 A 20170502; US 201716098238 A 20170502; US 202016880933 A 20200521; UY 37222 A 20170502