EP 3454652 A1 20190320 - SOLUTION FOR THE PRESERVATION, TRANSPORT AND APPLICATION OF STEM CELLS
Title (en)
SOLUTION FOR THE PRESERVATION, TRANSPORT AND APPLICATION OF STEM CELLS
Title (de)
LÖSUNG ZUR KONSERVIERUNG, ZUM TRANSPORT UND ZUR ANWENDUNG VON STAMMZELLEN
Title (fr)
SOLUTION POUR LA CONSERVATION, LE TRANSPORT ET L'APPLICATION DE CELLULES SOUCHES
Publication
Application
Priority
- CZ 2016284 A 20160513
- IB 2017052832 W 20170513
Abstract (en)
[origin: WO2017195179A1] A solution for the preservation, transport and application of stem cells for medical utilisation, that consists ofa buffer water solution of trehalose. The solution contains cations K+ in a quantity of 20 to 50 mmol/1, cations Na+ in a quantity of 20 to 80 mmol/1; anions CI" in a quantity of 0.5 to 40 mmol/1, anions PO43" and/or HPO42" and/or H2PO4" in a total quantity of 20 to 65 mmol/1, and trehalose in a quantity of 60 to 300 mmol/1 as necessary components. The concentration of the components has been selected in such a way that the pH of the solution is 7.1 to 7.6. The solution is intended for storing the cells at a temperature of - 4 °C to 25 °C, advantageously 0 °C to 8 °C, and most frequently 4 °C to 6 °C. Adequate viability of the cells is kept for a period of at least 72 hours.. The solution consists of pharmaceutically acceptable compounds, and it can be used for application of the stem cells that are kept directly within. The solution containing the stem cells is intended for the treatment of inflammatory diseases including post-traumatic inflammatory reactions after damage or injury, as well as for treatment of degenerative and neurodegenerative diseases. The solution containing the stem cells can also be used for the treatment of trauma, of developmental defects, for healing of wounds and skin burns, for tissue replacement, for treatment of locomotion system diseases (tendons, joints, inflammatory diseases, arthritis, and osteoarthritis), bone defects, diabetes, attacks, and cardiological and oncological diseases.
IPC 8 full level
A01N 1/02 (2006.01); A61K 9/10 (2006.01); A61K 35/28 (2015.01); A61K 47/36 (2006.01); C12N 5/00 (2006.01); C12N 5/0775 (2010.01)
CPC (source: EP)
A01N 1/021 (2013.01); A01N 1/0221 (2013.01); C12N 5/0068 (2013.01); C12N 5/0605 (2013.01); C12N 5/0663 (2013.01); C12N 5/0667 (2013.01); A61K 35/28 (2013.01); C12N 2500/12 (2013.01); C12N 2500/14 (2013.01); C12N 2500/34 (2013.01)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017195179 A1 20171116; CZ 2016284 A3 20170712; CZ 306800 B6 20170712; EP 3454652 A1 20190320; EP 3454652 A4 20200101
DOCDB simple family (application)
IB 2017052832 W 20170513; CZ 2016284 A 20160513; EP 17795730 A 20170513