EP 3455253 A1 20190320 - C-TERMINALLY FUSED TNF FAMILY LIGAND TRIMER-CONTAINING ANTIGEN BINDING MOLECULES
Title (en)
C-TERMINALLY FUSED TNF FAMILY LIGAND TRIMER-CONTAINING ANTIGEN BINDING MOLECULES
Title (de)
C-TERMINAL-FUSIONIERTE ANTIGENBINDENDE MOLEKÜLE MIT LIGANDENTRIMER DER TNF-FAMILIE
Title (fr)
MOLÉCULES DE LIAISON À L'ANTIGÈNE CONTENANT UN TRIMÈRE DE LIGAND DE LA FAMILLE DU TNF FUSIONNÉ À L'EXTRÉMITÉ C-TERMINALE
Publication
Application
Priority
- EP 16169237 A 20160511
- EP 2017060863 W 20170508
Abstract (en)
[origin: EP3243836A1] The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) a Fab domain capable of specific binding to a target cell antigen, (b) a Fc domain composed of a first and a second subunit capable of stable association, and (c) a first polypeptide comprising two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and a second polypeptide comprising one ectodomain of said TNF ligand family member or a fragment thereof, wherein the first polypeptide is fused at its N-terminus to the C-terminus of one of the subunits of the Fc domain and wherein the second polypeptide is fused at its N-terminus to the C-terminus of the other subunit of the Fc domain.
IPC 8 full level
C07K 16/24 (2006.01); A61K 39/395 (2006.01); C07K 14/705 (2006.01); C07K 14/715 (2006.01); C07K 16/14 (2006.01); C07K 16/28 (2006.01)
CPC (source: EP US)
A61K 39/395 (2013.01 - EP US); A61K 47/6813 (2017.07 - EP US); A61K 47/6835 (2017.07 - EP US); A61P 35/00 (2017.12 - EP); C07K 14/70575 (2013.01 - EP US); C07K 14/70578 (2013.01 - US); C07K 14/7151 (2013.01 - EP US); C07K 16/14 (2013.01 - EP US); C07K 16/241 (2013.01 - EP US); C07K 16/2803 (2013.01 - EP US); C07K 16/3007 (2013.01 - US); C07K 16/40 (2013.01 - US); C07K 2317/24 (2013.01 - US); C07K 2317/55 (2013.01 - US); C07K 2317/92 (2013.01 - US); C07K 2319/30 (2013.01 - EP US)
Citation (search report)
See references of WO 2017194438A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3243836 A1 20171115; CN 109311973 A 20190205; CN 109311973 B 20230404; EP 3455253 A1 20190320; EP 3455253 B1 20210407; JP 2019521655 A 20190808; JP 7043422 B2 20220329; US 2019194291 A1 20190627; US 2021009656 A1 20210114; WO 2017194438 A1 20171116
DOCDB simple family (application)
EP 16169237 A 20160511; CN 201780030382 A 20170508; EP 17724512 A 20170508; EP 2017060863 W 20170508; JP 2018559278 A 20170508; US 201816184147 A 20181108; US 202017030251 A 20200923