EP 3458445 B1 20210217 - KRAS G12C INHIBITORS
Title (en)
KRAS G12C INHIBITORS
Title (de)
KRAS-G12C-INHIBITOREN
Title (fr)
INHIBITEURS DE KRAS G12C
Publication
Application
Priority
- US 201662338116 P 20160518
- US 201762444614 P 20170110
- US 2017033099 W 20170517
Abstract (en)
[origin: WO2017201161A1] The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
IPC 8 full level
C07D 231/56 (2006.01); A61K 31/445 (2006.01); C07D 295/185 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP IL KR US)
A61K 31/519 (2013.01 - IL KR); A61K 31/5377 (2013.01 - IL KR); A61K 31/541 (2013.01 - KR); A61K 31/55 (2013.01 - KR); A61P 35/00 (2018.01 - EP IL KR US); A61P 35/02 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 471/04 (2013.01 - EP IL KR US); C07D 487/10 (2013.01 - IL KR); C07D 491/08 (2013.01 - KR); C07D 519/00 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017201161 A1 20171123; AU 2017266911 A1 20181206; AU 2017266911 B2 20210902; CA 3024523 A1 20171123; CN 109843856 A 20190604; CN 109843856 B 20230502; EP 3458445 A1 20190327; EP 3458445 A4 20191113; EP 3458445 B1 20210217; ES 2863873 T3 20211011; IL 262867 A 20190331; IL 262867 B 20220101; JP 2019516718 A 20190620; JP 7039489 B2 20220322; KR 102444509 B1 20220919; KR 20190039475 A 20190412; MX 2018013983 A 20190816; SG 11201810171S A 20181228; US 10125134 B2 20181113; US 10633381 B2 20200428; US 11267812 B2 20220308; US 2018072723 A1 20180315; US 2019062330 A1 20190228; US 2021269432 A1 20210902
DOCDB simple family (application)
US 2017033099 W 20170517; AU 2017266911 A 20170517; CA 3024523 A 20170517; CN 201780044670 A 20170517; EP 17800088 A 20170517; ES 17800088 T 20170517; IL 26286718 A 20181107; JP 2018560589 A 20170517; KR 20187036747 A 20170517; MX 2018013983 A 20170517; SG 11201810171S A 20170517; US 201715814279 A 20171115; US 201716099398 A 20170517; US 201816173726 A 20181029