EP 3464608 A4 20200129 - THERAPEUTIC RECOMBINANT KLOTHO PROTEINS AND COMPOSITIONS AND METHODS INVOLVING THE SAME
Title (en)
THERAPEUTIC RECOMBINANT KLOTHO PROTEINS AND COMPOSITIONS AND METHODS INVOLVING THE SAME
Title (de)
THERAPEUTISCHE REKOMBINANTE KLOTHO-PROTEINE SOWIE ZUSAMMENSETZUNGEN UND VERFAHREN DAMIT
Title (fr)
PROTÉINES KLOTHO RECOMBINÉES THÉRAPEUTIQUES ET COMPOSITIONS ET MÉTHODES COMPRENANT CELLES-CI
Publication
Application
Priority
- US 201662344743 P 20160602
- US 201662375046 P 20160815
- US 201662401600 P 20160929
- US 201662425237 P 20161122
- US 201762456318 P 20170208
- US 2017035755 W 20170602
Abstract (en)
[origin: WO2017210607A1] Recombinant Klotho proteins and variants, nucleic acids encoding the same, cell lines and suspension cultures expressing the same, and method of manufacturing and administering the same are disclosed. Proteins include solubility or half-life-extending features like glycosylation and fusion protein tags. Proteins have at least 85% amino acid sequence identity to a portion of human alpha Klotho isoform 1. Treatment protocols include determining serum soluble Klotho level in a subject, calculating a dosage of the protein sufficient to raise the serum soluble Klotho level in the subject to a predetermined level, administering the dosage of protein to the subject, such as by bolus or gradual injection, determining a rate of Klotho protein decline in the serum of the subject following administration of the first dosage, calculating a time and amount of a subsequent dosage of the Klotho protein, and administering the subsequent dosage of Klotho protein to the subject.
IPC 8 full level
C12P 21/06 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/22 (2006.01)
CPC (source: CN EP KR)
A61K 38/22 (2013.01 - EP); A61K 38/47 (2013.01 - KR); A61P 13/12 (2018.01 - EP KR); C07K 14/47 (2013.01 - CN); C12N 5/0682 (2013.01 - CN); C12N 9/003 (2013.01 - CN KR); C12N 9/2402 (2013.01 - KR); C12N 9/93 (2013.01 - CN KR); C12N 15/85 (2013.01 - KR); C12P 21/02 (2013.01 - CN EP); C12Y 105/01003 (2013.01 - CN); C12Y 302/01031 (2013.01 - EP); C12Y 603/01002 (2013.01 - CN); C12N 2501/70 (2013.01 - KR); C12N 2510/02 (2013.01 - KR); C12Y 105/01003 (2013.01 - KR); C12Y 302/01031 (2013.01 - KR); C12Y 603/01002 (2013.01 - KR)
Citation (search report)
- [XI] WO 0027885 A1 20000518 - KYOWA HAKKO KOGYO KK [JP], et al
- [X] YAMAZAKI Y ET AL: "Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 398, no. 3, 30 July 2010 (2010-07-30), pages 513 - 518, XP027185031, ISSN: 0006-291X, [retrieved on 20100701], DOI: 10.1016/J.BBRC.2010.06.110
- [X] KATO YUKINARI ET AL: "Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 267, no. 2, 19 January 2000 (2000-01-19), pages 597 - 602, XP002572556, ISSN: 0006-291X, DOI: 10.1006/BBRC.1999.2009
- See also references of WO 2017210607A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017210607 A1 20171207; AU 2017272349 A1 20181122; AU 2017272349 B2 20221201; BR 112018073909 A2 20190226; CA 3025461 A1 20171207; CN 109219663 A 20190115; CN 116478907 A 20230725; EP 3464608 A1 20190410; EP 3464608 A4 20200129; JP 2019526272 A 20190919; JP 2023123565 A 20230905; KR 102570250 B1 20230829; KR 20190015711 A 20190214; KR 20230125857 A 20230829; MX 2018014753 A 20190617; MX 2023008626 A 20230808
DOCDB simple family (application)
US 2017035755 W 20170602; AU 2017272349 A 20170602; BR 112018073909 A 20170602; CA 3025461 A 20170602; CN 201780034374 A 20170602; CN 202310383190 A 20170602; EP 17807601 A 20170602; JP 2019515786 A 20170602; JP 2023096236 A 20230612; KR 20187034860 A 20170602; KR 20237028237 A 20170602; MX 2018014753 A 20170602; MX 2023008626 A 20181129