EP 3468619 A1 20190417 - RADIO-PHARMACEUTICAL COMPLEXES
Title (en)
RADIO-PHARMACEUTICAL COMPLEXES
Title (de)
RADIOPHARMAZEUTISCHE KOMPLEXE
Title (fr)
COMPLEXES RADIOPHARMACEUTIQUES
Publication
Application
Priority
- EP 16173874 A 20160610
- EP 2017063689 W 20170606
Abstract (en)
[origin: WO2017211809A1] The invention provides a method for the formation of a tissue-targeting thorium complex, said method comprising; a) forming an octadentate chelator comprising four hydroxypyridinone (HOPO) moieties, substituted in the N-position with a methyl group, and a coupling moiety terminating in a carboxylic acid group; b) coupling said octadentate chelator to at least one tissue-targeting moiety targeting prolyl endopeptidase FAP; and c) contacting said tissue-targeting chelator with an aqueous solution comprising an ion of at least one alpha-emitting thorium isotope. A method of treatment of a neoplastic or hyperplastic disease comprising admistration of such a tissue-targeting thorium complex, as well as the complex and corresponding pharmaceutical formulations are also provided.
IPC 8 full level
A61K 51/04 (2006.01); A61K 51/10 (2006.01); A61P 35/00 (2006.01); C07D 213/81 (2006.01)
CPC (source: EA EP KR US)
A61K 51/0478 (2013.01 - EA EP KR US); A61K 51/0482 (2013.01 - US); A61K 51/1075 (2013.01 - EA EP KR US); A61K 51/1093 (2013.01 - US); A61P 35/00 (2018.01 - EP KR); C07D 213/81 (2013.01 - EA EP KR US); A61K 2121/00 (2013.01 - KR)
Citation (examination)
E. FISCHER ET AL: "Radioimmunotherapy of Fibroblast Activation Protein Positive Tumors by Rapidly Internalizing Antibodies", CLINICAL CANCER RESEARCH, vol. 18, no. 22, 19 September 2012 (2012-09-19), US, pages 6208 - 6218, XP055257958, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-12-0644
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2017211809 A1 20171214; AR 110466 A1 20190403; AU 2017277463 A1 20190103; BR 112018075554 A2 20191001; CA 3026900 A1 20171214; CL 2018003550 A1 20190201; CN 109689115 A 20190426; CO 2018013359 A2 20181214; CR 20180581 A 20190211; CU 20180149 A7 20190704; DO P2018000277 A 20181231; EA 201892814 A1 20190628; EC SP18091468 A 20181231; EP 3468619 A1 20190417; IL 263538 A 20190131; JP 2019517547 A 20190624; KR 20190016544 A 20190218; MA 45225 A 20190417; MX 2018015340 A 20190328; NI 201800136 A 20190429; PE 20190327 A1 20190305; PH 12018502605 A1 20191021; SG 11201810967V A 20190130; TW 201805025 A 20180216; US 2019298865 A1 20191003; UY 37286 A 20180131
DOCDB simple family (application)
EP 2017063689 W 20170606; AR P170101585 A 20170609; AU 2017277463 A 20170606; BR 112018075554 A 20170606; CA 3026900 A 20170606; CL 2018003550 A 20181210; CN 201780049257 A 20170606; CO 2018013359 A 20181210; CR 20180581 A 20170606; CU 20180149 A 20170606; DO 2018000277 A 20181210; EA 201892814 A 20170606; EC DI201891468 A 20181210; EP 17729086 A 20170606; IL 26353818 A 20181206; JP 2018564263 A 20170606; KR 20197000406 A 20170606; MA 45225 A 20170606; MX 2018015340 A 20170606; NI 201800136 A 20181210; PE 2018003200 A 20170606; PH 12018502605 A 20181210; SG 11201810967V A 20170606; TW 106119188 A 20170609; US 201716308307 A 20170606; UY 37286 A 20170609