EP 3469069 A4 20200122 - COMPOSITIONS AND METHODS INCLUDING B LYMPHOCYTE CELL LINE EXPRESSING MEMBRANE IMMUNOGLOBULIN DIFFERENT FROM SECRETED IMMUNOGLOBULIN AND CYTOLYTIC FUNCTION
Title (en)
COMPOSITIONS AND METHODS INCLUDING B LYMPHOCYTE CELL LINE EXPRESSING MEMBRANE IMMUNOGLOBULIN DIFFERENT FROM SECRETED IMMUNOGLOBULIN AND CYTOLYTIC FUNCTION
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN MIT B-LYMPHOZYT-ZELL-LINIE, DIE EIN UNTERSCHIEDLICHES MEMBRANIMMUNGLOBULIN ALS SEKRETIERTES IMMUNGLOBULIN EXPRIMIERT, UND ZYTOLYSEFUNKTION
Title (fr)
COMPOSITIONS ET PROCÉDÉS COMPRENANT UNE LIGNÉE CELLULAIRE DE LYMPHOCYTES B EXPRIMANT UNE IMMUNOGLOBULINE MEMBRANAIRE DIFFÉRENTE D'UNE IMMUNOGLOBULINE SÉCRÉTÉE ET FONCTION CYTOLYTIQUE
Publication
Application
Priority
- US 201615178715 A 20160610
- US 2017036521 W 20170608
Abstract (en)
[origin: WO2017214376A1] Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
IPC 8 full level
C12N 5/0781 (2010.01); A61K 35/12 (2015.01); A61K 35/17 (2015.01); A61K 38/17 (2006.01); C07K 16/00 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP)
A61K 38/177 (2013.01); A61K 38/1793 (2013.01); A61K 39/4612 (2023.05); A61K 39/4622 (2023.05); A61K 39/464493 (2023.05); A61K 39/464838 (2023.05); C07K 16/00 (2013.01); C12N 5/0635 (2013.01); C12N 15/85 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/58 (2023.05); C07K 2317/24 (2013.01); C12N 2510/00 (2013.01)
Citation (search report)
- [X] US 2015283177 A1 20151008 - HYDE RODERICK A [US], et al
- [Y] US 2007071717 A1 20070329 - WEINER GEORGE [US], et al
- [XP] US 2016355783 A1 20161208 - HYDE RODERICK A [US], et al
- [Y] MAGDALENA HAGN ET AL: "Why do human B cells secrete granzyme B? Insights into a novel B-cell differentiation pathway", ONCOIMMUNOLOGY, vol. 1, no. 8, 1 November 2012 (2012-11-01), pages 1368 - 1375, XP055449030, DOI: 10.4161/onci.22354
- See also references of WO 2017214376A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2017214376 A1 20171214; CN 109563482 A 20190402; EP 3469069 A1 20190417; EP 3469069 A4 20200122
DOCDB simple family (application)
US 2017036521 W 20170608; CN 201780047988 A 20170608; EP 17811004 A 20170608