EP 3484928 A4 20200226 - FUSION PROTEIN, POLYNUCLEOTIDE, GENETIC CONSTRUCT, PRODUCER, PREPARATION FOR REGENERATION OF CARTILAGE (VARIANTS)
Title (en)
FUSION PROTEIN, POLYNUCLEOTIDE, GENETIC CONSTRUCT, PRODUCER, PREPARATION FOR REGENERATION OF CARTILAGE (VARIANTS)
Title (de)
FUSIONSPROTEIN, POLYNUKLEOTID, GENETISCHES KONSTRUKT, HERSTELLER, ZUBEREITUNG ZUR REGENERATION VON GELENKKNORPEL (VARIANTEN)
Title (fr)
PROTÉINE DE FUSION, POLYNUCLÉOTIDE, CONSTRUCTION GÉNÉTIQUE, CELLULE PRODUCTRICE, PRÉPARATION POUR LA RÉGÉNÉRATION DU CARTILAGE (ET VARIANTES)
Publication
Application
Priority
- EA 201600575 A 20160714
- RU 2017000521 W 20170713
Abstract (en)
[origin: WO2018013013A1] The invention relates to molecular biology, biotechnology, medicine, veterinary science. A group of inventions is proposed: a fusion protein comprising a ligand to MATN1 protein, and a growth factor of EGF, TGF, FGF, IGF, the construct components are connected via a flexible link, characterized by the amino acid sequence of Fig. 1; such fusion protein further comprising the Fc-fragment of an antibody or a polypeptide binding with FcRn and/or transferrin or a fragment thereof, the construct components connected via a flexible link, characterized by the amino acid sequence of Fig. 1; encoding polynucleotide, codon-optimized for expression in the producer cells or a target organism, a genetic construct for the synthesis of the fusion protein in producer cells, or cells of a target organism, the fusion protein producer, a producer of a genetic construct based on a bacterial cell, a preparation for the regeneration of cartilage containing at least 1 fusion protein or genetic construct as the active agent, in an effective amount, and a physiologically acceptable carrier or buffer solution, for parenteral or, in the case of the preparation based on at least 1 fusion protein containing the transport domain, - oral administration, in the latter case the preparation is enclosed in an enteric coating, all - variants.
IPC 8 full level
C07K 19/00 (2006.01); A61K 38/10 (2006.01); A61K 38/18 (2006.01); A61K 38/40 (2006.01); A61P 19/02 (2006.01); C07K 7/08 (2006.01); C07K 14/475 (2006.01); C07K 14/78 (2006.01); C07K 14/79 (2006.01); C07K 16/46 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01)
CPC (source: EA EP KR US)
A61K 38/10 (2013.01 - EA KR); A61K 38/18 (2013.01 - EA KR); A61K 38/40 (2013.01 - EA KR); A61P 19/02 (2017.12 - EA EP KR US); C07K 7/08 (2013.01 - EA EP KR US); C07K 14/475 (2013.01 - EA US); C07K 14/485 (2013.01 - EP KR US); C07K 14/495 (2013.01 - EP KR US); C07K 14/50 (2013.01 - US); C07K 14/503 (2013.01 - EP KR US); C07K 14/65 (2013.01 - EP KR US); C07K 14/78 (2013.01 - EP); C07K 14/79 (2013.01 - EA EP KR US); C07K 16/46 (2013.01 - EA); C07K 19/00 (2013.01 - EA); C12N 9/6459 (2013.01 - EP US); C12N 15/62 (2013.01 - EA US); C12N 15/63 (2013.01 - EA); A61K 38/00 (2013.01 - EP US); C07K 2319/02 (2013.01 - EP KR US); C07K 2319/30 (2013.01 - EP KR US); C07K 2319/33 (2013.01 - EP KR US); C07K 2319/70 (2013.01 - EP KR US)
Citation (search report)
- [A] CN 101891803 A 20101124 - UNIV PEKING 3RD HOSPITAL
- [A] WO 2016013751 A1 20160128 - LEMONEX INC [KR], et al & EP 3173074 A1 20170531 - LEMONEX INC [KR], et al
- [A] WO 2014047741 A1 20140403 - UNIV BRITISH COLUMBIA [CA]
- [A] WO 2015108998 A2 20150723 - US HEALTH [US]
- [A] WIBERG CHARLOTTE ET AL: "Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 26 SEP 2003, vol. 278, no. 39, 26 September 2003 (2003-09-26), pages 37698 - 37704, XP002796864, ISSN: 0021-9258
- See references of WO 2018013013A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018013013 A1 20180118; CN 109563173 A 20190402; EA 037848 B1 20210527; EA 201600575 A1 20180131; EP 3484928 A1 20190522; EP 3484928 A4 20200226; IL 264174 A 20190228; KR 20190028505 A 20190318; US 11299724 B2 20220412; US 2019218539 A1 20190718
DOCDB simple family (application)
RU 2017000521 W 20170713; CN 201780043652 A 20170713; EA 201600575 A 20160714; EP 17828045 A 20170713; IL 26417419 A 20190109; KR 20197004225 A 20170713; US 201716316254 A 20170713