Global Patent Index - EP 3495019 A1

EP 3495019 A1 20190612 - A SYSTEM FOR PLANNING AND/OR PROVIDING NEUROSTIMULATION FOR A PATIENT

Title (en)

A SYSTEM FOR PLANNING AND/OR PROVIDING NEUROSTIMULATION FOR A PATIENT

Title (de)

SYSTEM ZUR PLANUNG UND/ODER BEREITSTELLUNG EINER NEUROSTIMULATION FÜR EINEN PATIENTEN

Title (fr)

SYSTÈME DE PLANIFICATION ET/OU DE FOURNITURE DE NEUROSTIMULATION POUR UN PATIENT

Publication

EP 3495019 A1 20190612 (EN)

Application

EP 17205362 A 20171205

Priority

EP 17205362 A 20171205

Abstract (en)

The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising- a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activation of the spinal cord of a patient,- a healthy spinal cord map storage module (50) for storing at least one reference map (51) describing physiological activation of the spinal cord of at least one healthy subject,- an analysis module (42) configured and arranged such that the pathological spinal cord map and the reference map can be compared and/or analyzed automatically such that a deviation map is created, the deviation map describing the difference between the pathological spinal cord map and the reference map, anda compensation module (52) which is configured and arranged to calculate on the basis of the deviation map a neurostimulation protocol for compensating the activation.Furthermore, the invention relates to a method for planning and/or providing neurostimulation for a patient.

IPC 8 full level

A61N 1/36 (2006.01); A61B 5/00 (2006.01); A61B 5/0488 (2006.01)

CPC (source: EP US)

A61B 5/395 (2021.01 - US); A61N 1/36062 (2017.07 - EP US); A61N 1/36067 (2013.01 - EP); A61N 1/36139 (2013.01 - EP US); G16H 20/30 (2017.12 - EP); A61B 5/389 (2021.01 - EP); A61B 5/4836 (2013.01 - EP); G16H 50/50 (2017.12 - EP)

Citation (applicant)

  • US 2016030750 A1 20160204 - BOKIL HEMANT [US], et al
  • US 2016001096 A1 20160107 - MISHELEVICH DAVID J [US]
  • EP 2810689 A1 20141210 - SAPIENS STEERING BRAIN STIMULATION BV [NL]
  • EP 2810690 A1 20141210 - SAPIENS STEERING BRAIN STIMULATION BV [NL]
  • US 2015066111 A1 20150305 - BLUM DAVID ARTHUR [US], et al
  • BIZZI, E. ET AL.: "Modular organization of motor behavior in the frog's spinal cord", TRENDS IN NEUROSCIENCES, vol. 18, 1995, pages 442 - 446, XP004556864, DOI: doi:10.1016/0166-2236(95)94494-P
  • LEVINE, A. J. ET AL.: "Identification of a cellular node for motor control pathways", NATURE NEUROSCIENCE, vol. 17, 2014, pages 586 - 593
  • VAN DEN BRAND R ET AL.: "Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury", SCIENCE, vol. 336, 2012, pages 1182 - 1185
  • ANGELI CA ET AL.: "Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans", BRAIN: A JOURNAL OF NEUROLOGY, vol. 137, 2014, pages 1394 - 1409
  • HARKEMA S ET AL.: "Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study", THE LANCET, vol. 377, pages 1938 - 1947, XP055080635, DOI: doi:10.1016/S0140-6736(11)60547-3
  • DANNER SM ET AL.: "Human spinal locomotor control is based on flexibly organized burst generators", BRAIN: A JOURNAL OF NEUROLOGY, vol. 138, 2015, pages 577 - 588
  • COURTINE G ET AL.: "Transformation of nonfunctional spinal circuits into functional states after the loss of brain input", NATURE NEUROSCIENCE, vol. 12, 2009, pages 1333 - 1342, XP055080636, DOI: doi:10.1038/nn.2401
  • CAPOGROSSO M ET AL.: "A brain-spine interface alleviating gait deficits after spinal cord injury in primates", NATURE, vol. 539, 2016, pages 284 - 288
  • CAPOGROSSO M ET AL.: "A computational model for epidural electrical stimulation of spinal sensorimotor circuits", THE JOURNAL OF NEUROSCIENCE: THE OFFICIAL JOURNAL OF THE SOCIETY FOR NEUROSCIENCE, vol. 33, 2013, pages 19326 - 19340
  • MORAUD EM ET AL.: "Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury", NEURON, vol. 89, 2016, pages 814 - 828, XP029421586, DOI: doi:10.1016/j.neuron.2016.01.009
  • RATTAY F ET AL.: "Epidural electrical stimulation of posterior structures of the human lumbosacral cord: 2. quantitative analysis by computer modeling", SPINAL CORD, vol. 38, 2000, pages 473 - 489
  • GERASIMENKO Y ET AL.: "Program No. 447.445", SOC. NEUROSCI. ABSTR.
  • MINASSIAN K ET AL.: "Human lumbar cord circuitries can be activated by extrinsic tonic input to generate locomotor-like activity", HUMAN MOVEMENT SCIENCE, vol. 26, 2007, pages 275 - 295, XP022001586, DOI: doi:10.1016/j.humov.2007.01.005
  • HARKEMA, S ET AL.: "Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study", THE LANCET, vol. 377, pages 1938 - 1947, XP055080635, DOI: doi:10.1016/S0140-6736(11)60547-3
  • BIZZI E ET AL.: "Modular organization of motor behavior in the frog's spinal cord", TRENDS IN NEUROSCIENCES, vol. 18, 1995, pages 442 - 446, XP004556864, DOI: doi:10.1016/0166-2236(95)94494-P
  • LEVINE AJ ET AL.: "Identification of a cellular node for motor control pathways", NATURE NEUROSCIENCE, vol. 17, 2014, pages 586 - 593
  • WENGER N ET AL.: "Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury", NAT MED, vol. 22, 2016, pages 138 - 145
  • CAPOGROSSO M ET AL.: "A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits", JOURNAL OF NEUROSCIENCE, vol. 33, no. 49, 4 December 2013 (2013-12-04), pages 19326 - 19340
  • COURTINE G ET AL.: "Transformation of nonfunctional spinal circuits into functional states after the loss of brain input", NAT NEUROSCI., vol. 12, no. 10, October 2009 (2009-10-01), pages 1333 - 1342, XP055080636, DOI: doi:10.1038/nn.2401
  • MORAUD EM ET AL.: "Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Deficits after Spinal Cord Injury", NEURON, vol. 89, no. 4, 17 February 2016 (2016-02-17), pages 814 - 828, XP029421586, DOI: doi:10.1016/j.neuron.2016.01.009

Citation (search report)

  • [I] US 2017173326 A1 20170622 - BLOCH JOCELYNE [CH], et al
  • [A] US 2016279418 A1 20160929 - COURTINE GREGOIRE [CH], et al
  • [I] MARCO CAPOGROSSO ET AL: "A brainspine interface alleviating gait deficits after spinal cord injury in primates", NATURE, vol. 539, 10 November 2016 (2016-11-10), pages 284 - 288, XP055479559, Retrieved from the Internet <URL:https://www.nature.com/articles/nature20118.pdf> [retrieved on 20180530], DOI: 10.1038/nature20118
  • [A] N. WENGER ET AL: "Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury", SCIENCE TRANSLATIONAL MEDICINE, vol. 6, no. 255, 24 September 2014 (2014-09-24), US, pages 255ra133 - 255ra133, XP055410746, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.3008325

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3495019 A1 20190612; EP 3720546 A1 20201014; EP 3720546 B1 20230301; US 11413459 B2 20220816; US 2020384272 A1 20201210; WO 2019110401 A1 20190613

DOCDB simple family (application)

EP 17205362 A 20171205; EP 18807368 A 20181129; EP 2018082946 W 20181129; US 201816769519 A 20181129