EP 3498303 A1 20190619 - METHODS OF PREPARATION OF CONJUGATES
Title (en)
METHODS OF PREPARATION OF CONJUGATES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON KONJUGATEN
Title (fr)
PROCÉDÉS DE PRÉPARATION DE CONJUGUÉS
Publication
Application
Priority
- US 201161443062 P 20110215
- US 201161443092 P 20110215
- US 201161483499 P 20110506
- EP 12705761 A 20120215
- US 2012025257 W 20120215
Abstract (en)
The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.
IPC 8 full level
A61K 47/68 (2017.01); A61P 35/00 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01)
CPC (source: BR CN EP IL KR RU US)
A61K 31/5517 (2013.01 - CN EP IL KR US); A61K 45/06 (2013.01 - IL US); A61K 47/545 (2017.08 - IL KR US); A61K 47/64 (2017.08 - KR); A61K 47/68035 (2023.08 - BR CN EP IL KR RU US); A61K 47/6849 (2017.08 - EP IL KR US); A61K 47/6851 (2017.08 - IL KR US); A61K 47/6867 (2017.08 - EP IL KR US); A61P 35/00 (2018.01 - EP IL KR US); C07D 487/04 (2013.01 - CN EP IL RU US); C07D 519/00 (2013.01 - CN EP IL US); C07K 16/30 (2013.01 - BR IL US); A61K 31/5517 (2013.01 - BR); A61K 45/06 (2013.01 - BR); A61K 47/545 (2017.08 - BR); A61K 47/6849 (2017.08 - BR); A61K 47/6851 (2017.08 - BR); A61K 47/6867 (2017.08 - BR); A61K 2039/505 (2013.01 - BR IL KR US); C07D 487/04 (2013.01 - BR); C07D 519/00 (2013.01 - BR); C07K 2317/24 (2013.01 - BR IL KR US); C07K 2317/92 (2013.01 - BR IL US); C07K 2317/94 (2013.01 - BR IL KR US)
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Citation (search report)
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- [AD] EP 2019104 A1 20090128 - SANOFI AVENTIS [FR]
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
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