EP 3498725 B1 20210609 - 19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID FOR USE IN THERAPY
Title (en)
19-NOR C3,3-DISUBSTITUTED C21-N-PYRAZOLYL STEROID FOR USE IN THERAPY
Title (de)
19-NOR-C3,3-DISUBSTITUIERTES C21-N-PYRAZOLYLSTEROID ZUR THERAPEUTISCHEN BEHANDLUNG
Title (fr)
STÉROÏDE 19-NOR C3,3-DISUBSTITUÉ C21-N-PYRAZOLYL POUR LE TRAITEMENT THÉRAPEUTIQUE
Publication
Application
Priority
- CN 2013074323 W 20130417
- EP 14785712 A 20140417
- CN 2014075594 W 20140417
Abstract (en)
[origin: WO2014169833A1] Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I), and pharmaceutically acceptable salts thereof; wherein-, R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
IPC 8 full level
C07J 43/00 (2006.01); A61K 31/57 (2006.01); A61K 31/573 (2006.01); A61K 31/58 (2006.01); A61P 25/00 (2006.01); C07J 1/00 (2006.01); C07J 3/00 (2006.01); C07J 5/00 (2006.01); C07J 7/00 (2006.01); C07J 13/00 (2006.01); C07J 15/00 (2006.01); C07J 21/00 (2006.01); C07J 31/00 (2006.01)
CPC (source: EP IL KR RU US)
A61K 9/0019 (2013.01 - IL US); A61K 31/573 (2013.01 - EP IL US); A61K 31/58 (2013.01 - EP IL KR RU US); A61P 9/00 (2018.01 - EP IL KR); A61P 25/00 (2018.01 - EP IL KR RU); A61P 25/04 (2018.01 - EP IL KR); A61P 25/08 (2018.01 - EP IL KR); A61P 25/14 (2018.01 - EP IL KR); A61P 25/18 (2018.01 - EP IL KR); A61P 25/20 (2018.01 - EP IL KR); A61P 25/22 (2018.01 - EP IL KR); A61P 25/28 (2018.01 - EP IL KR); A61P 25/30 (2018.01 - EP IL KR); A61P 27/16 (2018.01 - EP IL KR); C07J 1/0059 (2013.01 - IL); C07J 1/007 (2013.01 - IL); C07J 1/0074 (2013.01 - IL); C07J 3/00 (2013.01 - EP IL US); C07J 5/0015 (2013.01 - IL); C07J 5/0053 (2013.01 - EP IL US); C07J 7/00 (2013.01 - EP IL RU US); C07J 7/002 (2013.01 - IL); C07J 7/007 (2013.01 - IL); C07J 7/0085 (2013.01 - IL); C07J 13/007 (2013.01 - IL); C07J 15/00 (2013.01 - EP IL US); C07J 21/00 (2013.01 - IL); C07J 31/006 (2013.01 - IL); C07J 43/003 (2013.01 - EP IL KR RU US); C07J 1/0059 (2013.01 - EP US); C07J 1/007 (2013.01 - EP US); C07J 1/0074 (2013.01 - EP US); C07J 5/0015 (2013.01 - EP US); C07J 7/002 (2013.01 - EP US); C07J 7/007 (2013.01 - EP US); C07J 7/0085 (2013.01 - EP US); C07J 13/007 (2013.01 - EP US); C07J 21/00 (2013.01 - EP US); C07J 31/006 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2014169833 A1 20141023; WO 2014169833 A9 20160303; AU 2014256229 A1 20151105; AU 2014256229 A9 20160317; AU 2014256229 B2 20181004; AU 2018278844 A1 20190103; AU 2018278844 B2 20200716; AU 2020256400 A1 20201112; AU 2020256400 B2 20220428; AU 2022205157 A1 20220728; BR 112015026380 A2 20170725; BR 112015026380 A8 20191231; CA 2909545 A1 20141023; CN 105339381 A 20160217; CN 105339381 B 20180427; CN 108440633 A 20180824; CN 108440633 B 20210713; CN 113527400 A 20211022; CN 113527400 B 20240628; CY 1121228 T1 20200529; CY 1125416 T1 20230324; DK 2986623 T3 20190304; DK 3498725 T3 20210830; EP 2986623 A1 20160224; EP 2986623 A4 20160928; EP 2986623 B1 20181107; EP 3498725 A1 20190619; EP 3498725 B1 20210609; EP 3909966 A1 20211117; ES 2709434 T3 20190416; ES 2886182 T3 20211216; HK 1224301 A1 20170818; HR P20190232 T1 20190322; HR P20211314 T1 20211126; HU E041369 T2 20190528; HU E055554 T2 20211228; IL 242089 B 20201130; IL 278487 B 20211031; IL 286794 A 20211031; IL 286794 B1 20240201; IL 286794 B2 20240601; IL 310348 A 20240301; JP 2016517851 A 20160620; JP 2018199716 A 20181220; JP 2019001807 A 20190110; JP 2021001220 A 20210107; JP 2022058758 A 20220412; JP 2023154010 A 20231018; JP 6470258 B2 20190213; JP 6710730 B2 20200617; JP 6784735 B2 20201111; JP 7085601 B2 20220616; KR 102239541 B1 20210414; KR 102396328 B1 20220510; KR 102614507 B1 20231219; KR 20150143690 A 20151223; KR 20210041121 A 20210414; KR 20220062690 A 20220517; KR 20230172622 A 20231222; LT 2986623 T 20190225; LT 3498725 T 20210927; MX 2015014600 A 20160303; MX 2022007490 A 20220705; MX 362543 B 20190124; NZ 713303 A 20210326; PL 2986623 T3 20190430; PL 3498725 T3 20211108; PT 2986623 T 20190206; PT 3498725 T 20210909; RS 58297 B1 20190329; RS 62312 B1 20210930; RU 2015149008 A 20170522; RU 2018143835 A 20190116; RU 2675855 C2 20181225; SG 10201802389S A 20180427; SG 11201508550X A 20151127; SI 2986623 T1 20190329; SI 3498725 T1 20211130; TR 201901745 T4 20190321; US 10172871 B2 20190108; US 10342810 B2 20190709; US 11241446 B2 20220208; US 2016108080 A1 20160421; US 2017246191 A1 20170831; US 2018311262 A1 20181101; US 2020155576 A1 20200521; US 2022110950 A1 20220414; US 9512165 B2 20161206; ZA 201507740 B 20170927
DOCDB simple family (application)
CN 2014075594 W 20140417; AU 2014256229 A 20140417; AU 2018278844 A 20181211; AU 2020256400 A 20201015; AU 2022205157 A 20220712; BR 112015026380 A 20140417; CA 2909545 A 20140417; CN 201480031476 A 20140417; CN 201810263557 A 20140417; CN 202110717941 A 20140417; CY 191100154 T 20190205; CY 211100787 T 20210907; DK 14785712 T 20140417; DK 18203320 T 20140417; EP 14785712 A 20140417; EP 18203320 A 20140417; EP 21178047 A 20140417; ES 14785712 T 20140417; ES 18203320 T 20140417; HK 16109159 A 20160801; HR P20190232 T 20190205; HR P20211314 T 20210813; HU E14785712 A 20140417; HU E18203320 A 20140417; IL 24208915 A 20151015; IL 27848720 A 20201104; IL 28679421 A 20210929; IL 31034824 A 20240123; JP 2016507995 A 20140417; JP 2018164995 A 20180904; JP 2018164996 A 20180904; JP 2020161921 A 20200928; JP 2022010037 A 20220126; JP 2023129979 A 20230809; KR 20157032454 A 20140417; KR 20217010184 A 20140417; KR 20227015252 A 20140417; KR 20237042912 A 20140417; LT 14785712 T 20140417; LT 18203320 T 20140417; MX 2015014600 A 20140417; MX 2022007490 A 20151016; NZ 71330314 A 20140417; PL 14785712 T 20140417; PL 18203320 T 20140417; PT 14785712 T 20140417; PT 18203320 T 20140417; RS P20190136 A 20140417; RS P20211106 A 20140417; RU 2015149008 A 20140417; RU 2018143835 A 20140417; SG 10201802389S A 20140417; SG 11201508550X A 20140417; SI 201431072 T 20140417; SI 201431867 T 20140417; TR 201901745 T 20140417; US 201414785171 A 20140417; US 201615297845 A 20161019; US 201816020641 A 20180627; US 201916428386 A 20190531; US 202117560732 A 20211223; ZA 201507740 A 20151015