EP 3510052 A4 20200617 - METHOD FOR PREPARING AN EXTRACT OF HEVEA LATEX AND COMPOSITION THEREOF
Title (en)
METHOD FOR PREPARING AN EXTRACT OF HEVEA LATEX AND COMPOSITION THEREOF
Title (de)
VERFAHREN ZUR HERSTELLUNG EINES EXTRAKTS AUS HEVEA LATEX UND ZUSAMMENSETZUNG DARAUS
Title (fr)
PROCÉDÉ DE PRÉPARATION D'UN EXTRAIT DE LATEX D'HÉVÉA
Publication
Application
Priority
TH 2016000075 W 20160902
Abstract (en)
[origin: WO2018044242A1] The present disclosure provides for the method of preparing, from serum of calendered acidified Hevea latex, an extract that is rich in low-molecular weight carbohydrates and having anti-cancer activity. The method comprises the steps of: obtaining the serum released when acidified Hevea latex is calendered; optionally removing debris and micro-organisms from the serum; removing proteins; removing quebrachitol and small polar molecules; optionally dissolving the remaining solid powder in water; further removing proteins by treatment with acid; optionally neutralizing the excess acid; precipitating with solvent; collecting the precipitate; and optionally freeze drying the precipitate. The disclosure also provides for the method of treating cancer growth and/or metastasis and the method of inhibiting tumor cell proliferation in a patient. Furthermore, there are provided a pharmaceutical composition and a functional food composition comprising the disclosed extract of Hevea latex.
IPC 8 full level
C08C 1/02 (2006.01); A61K 36/47 (2006.01); A61P 35/00 (2006.01); C08C 1/04 (2006.01); C08C 2/02 (2006.01); C08L 7/02 (2006.01)
CPC (source: EP)
A61K 36/47 (2013.01); A61P 35/00 (2017.12); C08C 1/04 (2013.01); A61K 2236/333 (2013.01); A61K 2236/39 (2013.01); A61K 2236/51 (2013.01)
Citation (search report)
- [ID] VERONICA LAM UNIVERSITI ET AL: "Cell Viability Assay Guided Fractionation of Natural Rubber Latex Sera WNT signaling pathway View project Metal oxide Nanoparticles View project Sunderasan Elumalai Malaysian Rubber Board 49 PUBLICATIONS547 CITATIONS SEE PROFILE Ming Thong Ong", 1 January 2013 (2013-01-01), XP055691813, Retrieved from the Internet <URL:https://www.researchgate.net/profile/Sunderasan_Elumalai/publication/256706810_Cell_Viability_Assay_Guided_Fractionation_of_Natural_Rubber_Latex_Sera/links/00b7d523aaeb14aa3c000000/Cell-Viability-Assay-Guided-Fractionation-of-Natural-Rubber-Latex-Sera.pdf> [retrieved on 20200505]
- [T] S. BELLACICCO ET AL: "The Sugar and Polyol Composition of Hevea Brasiliensis Latex Depends on the Clonal Origin of the Tree", JOURNAL OF RUBBER RESEARCH, vol. 21, no. 3, 1 September 2018 (2018-09-01), MY, pages 224 - 235, XP055691814, ISSN: 1511-1768, DOI: 10.1007/BF03449172
- See references of WO 2018044242A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018044242 A1 20180308; CN 110023342 A 20190716; CN 110023342 B 20220111; EP 3510052 A1 20190717; EP 3510052 A4 20200617; MY 197240 A 20230607
DOCDB simple family (application)
TH 2016000075 W 20160902; CN 201680090627 A 20160902; EP 16915342 A 20160902; MY PI2019002474 A 20160902