EP 3519827 A1 20190807 - METHODS FOR TREATING CANCER WITH BAVITUXIMAB BASED ON LEVELS OF 2-GLYCOPROTEIN 1, AND ASSAYS THEREFOR
Title (en)
METHODS FOR TREATING CANCER WITH BAVITUXIMAB BASED ON LEVELS OF 2-GLYCOPROTEIN 1, AND ASSAYS THEREFOR
Title (de)
VERFAHREN ZUR BEHANDLUNG VON KREBS MIT BAVITUXIMAB AUF DER BASIS VON 2-GLYCOPROTEIN 1 UND TESTS DAFÜR
Title (fr)
PROCÉDÉ DE TRAITEMENT DU CANCER À L'AIDE DE BAVITUXIMAB SUR LA BASE DE NIVEAUX DE 2-GLYCOPROTÉINE 1, ET DOSAGES ASSOCIÉS
Publication
Application
Priority
- US 201662400589 P 20160927
- US 201662406727 P 20161011
- US 201762480994 P 20170403
- US 201762507580 P 20170517
- US 2017053370 W 20170926
Abstract (en)
[origin: WO2018064013A1] Disclosed are surprising new methods and kits for identifying and treating patients treatable with PS-targeting antibodies, particularly for identifying and treating cancer patients using bavituximab and bavituximab combination therapies. The methods and kits are based on the surprising finding that defined ranges of pre-treatment blood concentrations of β2-glycoprotein 1 (β2GΡΙ), particularly functional β2GPI, act as an indicator to accurately predict patients with better treatment outcomes.
IPC 8 full level
C07K 16/28 (2006.01); G01N 33/574 (2006.01); G01N 33/92 (2006.01)
CPC (source: EP KR)
A61K 31/337 (2013.01 - EP); A61K 31/44 (2013.01 - EP); A61K 31/555 (2013.01 - EP); A61K 31/7068 (2013.01 - EP); A61K 39/39558 (2013.01 - EP KR); A61K 45/06 (2013.01 - KR); A61P 35/00 (2017.12 - EP KR); C07K 16/28 (2013.01 - EP KR); C07K 16/2818 (2013.01 - EP KR); C07K 16/2827 (2013.01 - EP KR); C07K 16/44 (2013.01 - EP KR); G01N 33/57488 (2013.01 - EP KR); G01N 33/92 (2013.01 - EP KR); A61K 2039/505 (2013.01 - EP KR); A61K 2039/507 (2013.01 - EP KR); C07K 2317/24 (2013.01 - EP); C07K 2317/76 (2013.01 - EP); G01N 2400/00 (2013.01 - EP KR); G01N 2800/52 (2013.01 - EP KR)
Citation (search report)
See references of WO 2018064013A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2018064013 A1 20180405; WO 2018064013 A8 20190523; WO 2018064013 A9 20180705; AU 2017334698 A1 20190321; CA 3037008 A1 20180405; CN 109863402 A 20190607; EP 3519827 A1 20190807; JP 2019537619 A 20191226; KR 20190057303 A 20190528; MX 2019003569 A 20200722
DOCDB simple family (application)
US 2017053370 W 20170926; AU 2017334698 A 20170926; CA 3037008 A 20170926; CN 201780058161 A 20170926; EP 17791768 A 20170926; JP 2019538088 A 20170926; KR 20197008828 A 20170926; MX 2019003569 A 20170926