EP 3528810 A4 20200617 - BROMODOMAIN INHIBITOR
Title (en)
BROMODOMAIN INHIBITOR
Title (de)
BROMDOMÄNENINHIBITOR
Title (fr)
INHIBITEUR DE BROMODOMAINES
Publication
Application
Priority
- US 201662410756 P 20161020
- US 2017057439 W 20171019
Abstract (en)
[origin: WO2018075796A1] Described herein is the bromodomain inhibitor 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one, including crystalline forms, amorphous forms, solvates, and hydrates thereof, as well as pharmaceutical compositions that include this bromodomain inhibitor. In some embodiments the pharmaceutical composition comprises 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one that has been processed by micronization or spray dried dispersion. In some embodiments, the pharmaceutical composition further comprises at least one polymer. In some embodiments, the pharmaceutical compositions comprises a solid polymer matrix comprising 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one and at least one polymer. Pharmaceutical compositions comprising 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one are useful for the treatment of cancer or neoplastic disease.
IPC 8 full level
A61K 31/472 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01); A61P 35/00 (2006.01); C07D 217/22 (2006.01); C07D 217/24 (2006.01)
CPC (source: EP)
A61K 9/1641 (2013.01); A61K 9/1652 (2013.01); A61K 9/1694 (2013.01); A61K 9/2018 (2013.01); A61K 9/2054 (2013.01); A61K 31/472 (2013.01); A61P 35/00 (2018.01); C07D 217/24 (2013.01)
Citation (search report)
- [XP] WO 2016172618 A1 20161027 - CELGENE QUANTICEL RES INC [US]
- [I] WO 2015058160 A1 20150423 - QUANTICEL PHARMACEUTICALS INC [US]
- See also references of WO 2018075796A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018075796 A1 20180426; AR 109859 A1 20190130; AU 2017345468 A1 20190606; AU 2017345468 B2 20220602; CN 110099685 A 20190806; EP 3528810 A1 20190828; EP 3528810 A4 20200617; JP 2019535671 A 20191212; JP 2022095897 A 20220628; JP 2024056905 A 20240423; JP 7129973 B2 20220902; TW 201821062 A 20180616
DOCDB simple family (application)
US 2017057439 W 20171019; AR P170102935 A 20171020; AU 2017345468 A 20171019; CN 201780076154 A 20171019; EP 17862619 A 20171019; JP 2019521064 A 20171019; JP 2022066855 A 20220414; JP 2024021416 A 20240215; TW 106136093 A 20171020