EP 3534941 A4 20200708 - DNA ANTIBODY CONSTRUCTS FOR USE AGAINST LYME DISEASE
Title (en)
DNA ANTIBODY CONSTRUCTS FOR USE AGAINST LYME DISEASE
Title (de)
DNA-ANTIKÖRPER-KONSTRUKTE ZUR VERWENDUNG GEGEN LYME-BORRELIOSE
Title (fr)
CONSTRUCTIONS D'ANTICORPS ANTI-ADN À UTILISER CONTRE LA MALADIE DE LYME
Publication
Application
Priority
- US 201662418468 P 20161107
- US 2017060301 W 20171107
Abstract (en)
[origin: WO2018085801A1] Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Borrelia antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating lyme disease in a subject using said composition and method of generation.
IPC 8 full level
A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61P 31/04 (2006.01); C07K 14/20 (2006.01); C07K 16/12 (2006.01)
CPC (source: EP KR US)
A61K 39/0225 (2013.01 - US); A61P 31/04 (2018.01 - EP KR US); C07K 14/20 (2013.01 - EP KR US); C07K 16/1207 (2013.01 - EP KR US); A61K 2039/505 (2013.01 - EP KR US); A61K 2039/53 (2013.01 - EP KR US); C07K 2317/14 (2013.01 - EP KR US)
Citation (search report)
- [Y] WO 2014093894 A2 20140619 - UNIV PENNSYLVANIA [US], et al
- [X] WO 2016025331 A1 20160218 - UNIV MASSACHUSETTS [US]
- [A] SELEEKE FLINGAI ET AL: "Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy", SCIENTIFIC REPORTS, vol. 5, no. 1, 29 July 2015 (2015-07-29), XP055699048, DOI: 10.1038/srep12616
- [A] SELEEKE FLINGAI ET AL: "Generation of DNA Plasmid-Encoded Neutralizing Monoclonal Antibodies In Vivo, Abstract 428", MOLECULAR THERAPY VOLUME COPYRIGHT THE AMERICAN SOCIETY OF GENE & CELL THERAPY, 1 May 2016 (2016-05-01), XP055698778, Retrieved from the Internet <URL:https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(16)33237-3.pdf> [retrieved on 20200527]
- [X] SELEEKE FLINGAI: "University of Pennsylvania ScholarlyCommons Publicly Accessible Penn Dissertations Engineered DNA-Mediated Antibody Gene Transfer for Prophylaxis Against Infectious Diseases Engineered DNA-Mediated Antibody Gene Transfer for Prophylaxis Against Infectious Diseases", 1 January 2016 (2016-01-01), XP055698819, Retrieved from the Internet <URL:https://pdfs.semanticscholar.org/73bf/994fd8b4ea28359af0c82df9f0dd2a23d67e.pdf?_ga=2.33074750.1815083394.1590572847-161144235.1590435137> [retrieved on 20200527]
- [Y] YANG WANG ET AL: "Pre-exposure Prophylaxis With OspA-Specific Human Monoclonal Antibodies Protects Mice Against Tick Transmission of Lyme Disease Spirochetes", JOURNAL OF INFECTIOUS DISEASES. JID, vol. 214, no. 2, 18 April 2016 (2016-04-18), US, pages 205 - 211, XP055698830, ISSN: 0022-1899, DOI: 10.1093/infdis/jiw151
- See also references of WO 2018085801A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018085801 A1 20180511; CN 110167584 A 20190823; CN 110167584 B 20240607; EP 3534941 A1 20190911; EP 3534941 A4 20200708; JP 2020500033 A 20200109; JP 2023126321 A 20230907; KR 20190116975 A 20191015; KR 20210117359 A 20210928; KR 20230111264 A 20230725; RU 2019117601 A 20201207; RU 2019117601 A3 20210312; US 2019284261 A1 20190919
DOCDB simple family (application)
US 2017060301 W 20171107; CN 201780082386 A 20171107; EP 17867526 A 20171107; JP 2019545724 A 20171107; JP 2023111650 A 20230706; KR 20197016154 A 20171107; KR 20217030039 A 20171107; KR 20237023623 A 20171107; RU 2019117601 A 20171107; US 201716347861 A 20171107