EP 3538519 B1 20210728 - INDAZOLE DERIVATIVES AS ALPHA V INTEGRIN ANTAGONISTS
Title (en)
INDAZOLE DERIVATIVES AS ALPHA V INTEGRIN ANTAGONISTS
Title (de)
INDAZOLDERIVATE ALS ALPHA-V-INTEGRIN-ANTAGONISTEN
Title (fr)
DÉRIVÉS D'INDAZOLE EN TANT QU'ANTAGONISTES DE L'INTÉGRINE ALPHA V
Publication
Application
Priority
- US 201662418842 P 20161108
- US 2017060386 W 20171107
Abstract (en)
[origin: WO2018089357A1] The present invention provides compounds of Formula (Ia) or (Ib): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αV- containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αV-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
IPC 8 full level
C07D 401/14 (2006.01); A61K 31/404 (2006.01); A61P 35/00 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01)
CPC (source: EA EP KR US)
A61K 31/4375 (2013.01 - KR); A61K 31/4439 (2013.01 - KR); A61K 31/4709 (2013.01 - KR); A61K 31/498 (2013.01 - KR); A61K 31/4985 (2013.01 - KR); A61K 31/5355 (2013.01 - KR); A61K 31/5383 (2013.01 - KR); A61P 11/00 (2018.01 - EP KR); A61P 19/10 (2018.01 - EP KR); A61P 29/00 (2018.01 - EP KR); A61P 35/00 (2018.01 - EA EP KR US); A61P 37/02 (2018.01 - EP); A61P 37/06 (2018.01 - EP KR); A61P 43/00 (2018.01 - EP); C07D 401/04 (2013.01 - KR); C07D 401/14 (2013.01 - EA EP US); C07D 471/04 (2013.01 - EA EP KR US); C07D 487/04 (2013.01 - KR); C07D 498/04 (2013.01 - EA EP KR US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018089357 A1 20180517; AU 2017359027 A1 20190620; CA 3042714 A1 20180517; CN 110214137 A 20190906; EA 201991123 A1 20191129; EP 3538519 A1 20190918; EP 3538519 B1 20210728; ES 2886650 T3 20211220; IL 266472 A 20190731; JP 2019536768 A 20191219; JP 7213804 B2 20230127; KR 102506327 B1 20230303; KR 20190076033 A 20190701; MA 46745 A 20210331; MX 2019005243 A 20190805; US 10745384 B2 20200818; US 11028071 B2 20210608; US 2019256496 A1 20190822; US 2020339540 A1 20201029
DOCDB simple family (application)
US 2017060386 W 20171107; AU 2017359027 A 20171107; CA 3042714 A 20171107; CN 201780082125 A 20171107; EA 201991123 A 20171107; EP 17801234 A 20171107; ES 17801234 T 20171107; IL 26647219 A 20190506; JP 2019523838 A 20171107; KR 20197016080 A 20171107; MA 46745 A 20171107; MX 2019005243 A 20171107; US 201716347831 A 20171107; US 202016924346 A 20200709