EP 3538560 A4 20200617 - GDNF FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
Title (en)
GDNF FUSION POLYPEPTIDES AND METHODS OF USE THEREOF
Title (de)
GDNF-FUSIONSPOLYPEPTIDE UND VERFAHREN ZUR VERWENDUNG DAVON
Title (fr)
POLYPEPTIDES DE FUSION GDNF ET LEURS PROCÉDÉS D'UTILISATION
Publication
Application
Priority
- US 201662420480 P 20161110
- US 2017060953 W 20171109
Abstract (en)
[origin: WO2018089702A1] The present invention relates to compositions and methods of GDNF fusion polypeptides, wherein the GDNF fusion polypeptides include an Fc domain, an albumin-binding peptide, a fibronectin domain, or a human serum albumin, joined to a GDNF variant either directly or by the way of a linker. The GDNF fusion polypeptides may used to treat metabolic diseases, such as obesity and Type-1 and Type-2 diabetes, and neurological diseases, such as Amyotrophic lateral sclerosis (ALS) and Parkinson's disease.
IPC 8 full level
C07K 14/475 (2006.01); A61P 25/00 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); C12N 15/62 (2006.01)
CPC (source: EP US)
A61P 3/04 (2018.01 - US); A61P 3/10 (2018.01 - US); A61P 25/00 (2018.01 - EP US); C07K 14/4702 (2013.01 - EP US); C07K 14/475 (2013.01 - EP US); C07K 14/4756 (2013.01 - US); C07K 14/765 (2013.01 - US); C07K 14/78 (2013.01 - US); C07K 19/00 (2013.01 - US); A61K 38/00 (2013.01 - US); C07K 2319/30 (2013.01 - EP US); C07K 2319/31 (2013.01 - EP US)
Citation (search report)
- [A] WO 2010142035 A1 20101216 - ANGIOCHEM INC [CA], et al
- [XI] RUBEN J. BOADO ET AL: "GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier", BIOTECHNOLOGY AND BIOENGINEERING, vol. 100, no. 2, 1 June 2008 (2008-06-01), pages 387 - 396, XP055053563, ISSN: 0006-3592, DOI: 10.1002/bit.21764
- [I] SIMON MUSYOKA MWANGI ET AL: "Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 306, no. 6, 15 March 2014 (2014-03-15), US, pages G515 - G525, XP055692185, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00364.2013
- [A] Q.-H. ZHOU ET AL: "Monoclonal Antibody-Glial-Derived Neurotrophic Factor Fusion Protein Penetrates the Blood-Brain Barrier in the Mouse", DRUG METABOLISM AND DISPOSITION, vol. 38, no. 4, 1 April 2010 (2010-04-01), US, pages 566 - 572, XP055516687, ISSN: 0090-9556, DOI: 10.1124/dmd.109.031534
- [A] TUMER N ET AL: "Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity", NEUROBIOLOGY OF AGING, TARRYTOWN, NY, US, vol. 27, no. 3, 1 March 2006 (2006-03-01), pages 459 - 470, XP024993040, ISSN: 0197-4580, [retrieved on 20060301], DOI: 10.1016/J.NEUROBIOLAGING.2005.03.018
- See also references of WO 2018089702A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018089702 A1 20180517; AU 2017357931 A1 20190620; CA 3043179 A1 20180517; CN 110461880 A 20191115; EP 3538560 A1 20190918; EP 3538560 A4 20200617; JP 2019535267 A 20191212; US 11912750 B2 20240227; US 2019284251 A1 20190919; US 2024209048 A1 20240627
DOCDB simple family (application)
US 2017060953 W 20171109; AU 2017357931 A 20171109; CA 3043179 A 20171109; CN 201780082828 A 20171109; EP 17870175 A 20171109; JP 2019525814 A 20171109; US 201716348982 A 20171109; US 202418443769 A 20240216