Global Patent Index - EP 3541403 A4

EP 3541403 A4 20200812 - LIGAND IONOPHORE CONJUGATES

Title (en)

LIGAND IONOPHORE CONJUGATES

Title (de)

LIGAND-IONOPHOR-KONJUGATE

Title (fr)

CONJUGUÉS LIGAND-IONOPHORE

Publication

EP 3541403 A4 20200812 (EN)

Application

EP 17871348 A 20171116

Priority

  • US 201662422922 P 20161116
  • US 201762478063 P 20170329
  • US 2017061997 W 20171116

Abstract (en)

[origin: WO2018094035A2] The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.

IPC 8 full level

A61K 49/00 (2006.01); A61K 31/7088 (2006.01); A61K 38/08 (2019.01); A61K 47/55 (2017.01); A61P 35/00 (2006.01); G01N 33/533 (2006.01); G01N 33/84 (2006.01)

CPC (source: EP)

A61K 31/7088 (2013.01); A61K 47/551 (2017.08); A61K 47/552 (2017.08); A61K 49/0032 (2013.01); A61K 49/0052 (2013.01); A61K 49/0054 (2013.01); A61P 35/00 (2018.01)

Citation (search report)

  • [XP] WO 2016183131 A1 20161117 - PURDUE RESEARCH FOUNDATION [US] & - PURDUE RESEARCH FOUNDATION: "Priority document WO2016/183131", 17 November 2016 (2016-11-17), XP055711394, Retrieved from the Internet <URL:https://patentscope.wipo.int/search/docs2/pct/WO2016183131/pdf/Mx1gAMEXGK9Hvd6ZHKIlmMhqVHFA3UeIkz7jPgAaSjUO-KiG3gKnIGHX96bXV1E91Mui7g7TDC0l7GJiVt2K2Hyp83NOwRyoc9JBXfha5Th1Ml4pFzCwGjg4I0yMZRvP?docId=id00000035639729> [retrieved on 20200702]
  • [X] US 4919928 A 19900424 - JANSEN FRANZ [FR], et al
  • [XP] ESTEBAN A ORELLANA ET AL: "FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer", 2 August 2017 (2017-08-02), XP055711066, Retrieved from the Internet <URL:https://stm.sciencemag.org/content/scitransmed/9/401/eaam9327.full.pdf> [retrieved on 20200702] & ESTEBAN A ORELLANA ET AL: "Supplementary Information FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer", 2 August 2017 (2017-08-02), XP055711067, Retrieved from the Internet <URL:https://stm.sciencemag.org/content/scitransmed/suppl/2017/07/31/9.401.eaam9327.DC1/aam9327_SM.pdf> [retrieved on 20200702]
  • [XI] MINI THOMAS ET AL: "Ligand-Targeted Delivery of Small Interfering RNAs to Malignant Cells and Tissues", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1175, no. 1, 1 September 2009 (2009-09-01), pages 32 - 39, XP055046132, ISSN: 0077-8923, DOI: 10.1111/j.1749-6632.2009.04977.x
  • [A] ERINA VLASHI ET AL: "Effect of Folate-Targeted Nanoparticle Size on Their Rates of Penetration into Solid Tumors", ACS NANO, vol. 7, no. 10, 22 October 2013 (2013-10-22), US, pages 8573 - 8582, XP055711092, ISSN: 1936-0851, DOI: 10.1021/nn402644g
  • [A] GOOITZEN M VAN DAM ET AL: "Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-[alpha] targeting: first in-human results", NATURE MEDICINE, vol. 17, no. 10, 18 September 2011 (2011-09-18), New York, pages 1315 - 1319, XP055299051, ISSN: 1078-8956, DOI: 10.1038/nm.2472

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2018094035 A2 20180524; WO 2018094035 A3 20180628; CN 110167577 A 20190823; CN 110167577 B 20240510; EP 3541403 A2 20190925; EP 3541403 A4 20200812; JP 2019535719 A 20191212; JP 2022166047 A 20221101; JP 7116728 B2 20220810

DOCDB simple family (application)

US 2017061997 W 20171116; CN 201780083686 A 20171116; EP 17871348 A 20171116; JP 2019526213 A 20171116; JP 2022121625 A 20220729