Global Patent Index - EP 3548040 A1

EP 3548040 A1 20191009 - ORAL COMPOSITION FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX AND LARYNGOPHARYNGEAL REFLUX

Title (en)

ORAL COMPOSITION FOR THE TREATMENT OF GASTROESOPHAGEAL REFLUX AND LARYNGOPHARYNGEAL REFLUX

Title (de)

ORALE ZUSAMMENSETZUNG ZUR BEHANDLUNG VON GASTROÖSOPHAGEALEM REFLUX UND LARYNGOPHARYNGEALEM REFLUX

Title (fr)

COMPOSITION ORALE POUR LE TRAITEMENT DU REFLUX GASTRO-OESOPHAGIEN ET DU REFLUX PHARYNGO-LARYNGÉ

Publication

EP 3548040 A1 20191009 (EN)

Application

EP 17817880 A 20171121

Priority

  • IT 201600121601 A 20161130
  • IB 2017057291 W 20171121

Abstract (en)

[origin: WO2018100468A1] The present invention relates to a composition comprising at least one salt of alginic acid, hyaluronic acid, a natural molecule, and thickening agents. Said composition has been demonstrated to effectively counteract the discomfort caused by gastroesophageal reflux, preventing said reflux and alleviating the effects thereof on the mucosa. Indeed, the composition can also play an active role in the regeneration of tissue damaged by previous reflux.

IPC 8 full level

A61K 31/726 (2006.01); A61K 31/728 (2006.01); A61K 31/734 (2006.01); A61P 1/04 (2006.01)

CPC (source: EP)

A61K 31/726 (2013.01); A61K 31/728 (2013.01); A61K 31/734 (2013.01); A61P 1/04 (2018.01)

C-Set (source: EP)

  1. A61K 31/728 + A61K 2300/00
  2. A61K 31/726 + A61K 2300/00
  3. A61K 31/734 + A61K 2300/00

Citation (search report)

  • [I] WO 2014198605 A1 20141218 - NESTEC SA [CH]
  • [I] WO 2004073597 A2 20040902 - RECKITT BENCKISER HEALTHCARE [GB], et al
  • [A] US 2014079814 A1 20140320 - GUROL ISMAIL [US], et al
  • [I] WO 9963986 A1 19991216 - RECKITT & COLMANN PROD LTD [GB], et al
  • [I] WO 0067799 A1 20001116 - RECKITT & COLMANN PROD LTD [GB], et al
  • [I] H.K BATCHELOR ET AL: "An in vitro mucosal model for prediction of the bioadhesion of alginate solutions to the oesophagus", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 238, no. 1-2, 1 May 2002 (2002-05-01), AMSTERDAM, NL, pages 123 - 132, XP055390591, ISSN: 0378-5173, DOI: 10.1016/S0378-5173(02)00062-5
  • [A] CEVIK MUAZEZ ET AL: "Preliminary study of efficacy of hyaluronic acid on caustic esophageal burns in an experimental rat model", JOURNAL OF PEDIATRIC SURGERY, W. B. SAUNDERS COMPANY, US, vol. 48, no. 4, 12 April 2013 (2013-04-12), pages 716 - 723, XP028547632, ISSN: 0022-3468, DOI: 10.1016/J.JPEDSURG.2012.08.015

Citation (examination)

  • US 2006040894 A1 20060223 - HUNTER WILLIAM L [CA], et al
  • WO 2016065083 A1 20160428 - SYMIC BIOMEDICAL INC [US]
  • SHALU SURI ET AL: "Cell-Laden Hydrogel Constructs of Hyaluronic Acid, Collagen, and Laminin for Neural Tissue Engineering", TISSUE ENGINEERING PART A, vol. 16, no. 5, 1 May 2010 (2010-05-01), US, pages 1703 - 1716, XP055390775, ISSN: 1937-3341, DOI: 10.1089/ten.tea.2009.0381
  • B PALMIERI ET AL: "Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux.", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 31 December 2013 (2013-12-31), XP055372748, Retrieved from the Internet <URL:http://www.europeanreview.org/wp/wp-content/uploads/3272-3278.pdf> [retrieved on 20170515]
  • KHAN SY ET AL: "Studies on Rheological Behavior of Xanthan Gum Solutions in Presence of Additives Studies on Rheological Behavior of Xanthan Gum Solutions in Presence of Additives", PETROLEUM & PETROCHEMICAL ENGINEERING JOURNAL, 13 August 2018 (2018-08-13), XP055961501, Retrieved from the Internet <URL:https://medwinpublishers.com/PPEJ/PPEJ16000165.pdf> [retrieved on 20220915]
  • RAMAKRISHNA CHETANA ET AL: "Rheological behavior of syrups containing sugar substitutes", EUROPEAN FOOD RESEARCH AND TECHNOLOGY, vol. 218, no. 4, 1 March 2004 (2004-03-01), pages 345 - 348, XP055086963, ISSN: 1438-2377, DOI: 10.1007/s00217-004-0876-7
  • SNETKOV PETR ET AL: "Hyaluronic Acid: The Influence of Molecular Weight on Structural, Physical, Physico-Chemical, and Degradable Properties of Biopolymer", POLYMERS, vol. 12, no. 8, 11 October 2020 (2020-10-11), CH, pages 1800, XP055961734, ISSN: 2073-4360, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/ivip/2073-4360/12/8/1800> DOI: 10.3390/polym12081800
  • YANG XIAO HONG ET AL: "Viscosity properties of sodium carboxymethylcellulose solutions", CELLULOSE, SPRINGER NETHERLANDS, NETHERLANDS, vol. 14, no. 5, 29 June 2007 (2007-06-29), pages 409 - 417, XP037829528, ISSN: 0969-0239, [retrieved on 20070629], DOI: 10.1007/S10570-007-9137-9
  • CASAS J?A ET AL: "Viscosity of guar gum and xanthan/guar gum mixture solutions", JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, vol. 80, no. 12, 1 January 2000 (2000-01-01), GB, pages 1722 - 1727, XP055961743, ISSN: 0022-5142, DOI: 10.1002/1097-0010(20000915)80:12<1722::AID-JSFA708>3.0.CO;2-X
  • See also references of WO 2018100468A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

WO 2018100468 A1 20180607; EP 3548040 A1 20191009; IT 201600121601 A1 20180530

DOCDB simple family (application)

IB 2017057291 W 20171121; EP 17817880 A 20171121; IT 201600121601 A 20161130