EP 3548087 A1 20191009 - NUCLEOSIDE TRIPHOSPHATE AND NUCLEOSIDE TRIPHOSPHATE ANALOGUE PRODRUGS
Title (en)
NUCLEOSIDE TRIPHOSPHATE AND NUCLEOSIDE TRIPHOSPHATE ANALOGUE PRODRUGS
Title (de)
NUKLEOSIDTRIPHOSPHAT UND NUKLEOSIDTRIPHOSPHAT-ANALOG-PRODRUGS
Title (fr)
PROMÉDICAMENTS DE NUCLÉOSIDE TRIPHOSPHATE ET D'ANALOGUES DE NUCLÉOSIDE TRIPHOSPHATE
Publication
Application
Priority
- LU 93331 A 20161202
- DE 102016123363 A 20161202
- EP 2017081140 W 20171201
Abstract (en)
[origin: WO2018100137A1] The invention relates to nucleoside triphosphate and nucleoside triphosphate analogue prodrugs. It is an object of the present invention to provide improved nucleoside triphosphate or nucleoside triphosphate analogue prodrugs. To achieve the object, the present invention provides in one aspect non-symmetrically double modified nucleoside triphosphate compounds, or their analogues, wherein the modification is carried out at the terminal, i.e. the γ-phosphate, or the corresponding analogous group, and wherein the first modification is adding a moiety A being intracellular stable, and the second modification is adding an intracellular labile mask B, which is cleaved within the cell, such that a nucleoside triphosphate or analogue thereof mono-modified with the intracellularly stable moiety A is released in the cell.
IPC 8 full level
A61K 47/54 (2017.01); A61K 31/7072 (2006.01); A61K 31/708 (2006.01); A61P 31/12 (2006.01); A61P 31/16 (2006.01); A61P 31/18 (2006.01); C07H 19/10 (2006.01); C07H 19/207 (2006.01)
CPC (source: EP)
A61K 31/7072 (2013.01); A61K 31/708 (2013.01); A61K 47/54 (2017.07); A61P 31/12 (2017.12); A61P 31/16 (2017.12); A61P 31/18 (2017.12); C07H 19/10 (2013.01); C07H 19/20 (2013.01)
Citation (search report)
See references of WO 2018100137A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
DOCDB simple family (application)
EP 2017081140 W 20171201; EP 17821806 A 20171201