EP 3558289 A1 20191030 - METHODS AND COMPOSITIONS FOR PREVENTING OR MINIMIZING EPITHELIAL-MESENCHYMAL TRANSITION
Title (en)
METHODS AND COMPOSITIONS FOR PREVENTING OR MINIMIZING EPITHELIAL-MESENCHYMAL TRANSITION
Title (de)
VERFAHREN UND ZUSAMMENSETZUNGEN ZUR PRÄVENTION ODER MINIMIERUNG DES EPITHELIALEN-MESENCHYMALEN ÜBERGANGS
Title (fr)
MÉTHODES ET COMPOSITIONS POUR PRÉVENIR OU RÉDUIRE AU MINIMUM LA TRANSITION ÉPITHÉLIO-MÉSENCHYMATEUSE
Publication
Application
Priority
- US 201662437123 P 20161221
- US 201762462530 P 20170223
- IB 2017001593 W 20171220
Abstract (en)
[origin: WO2018115953A1] Compositions, including albumin compositions, which inhibit or reduce epithelial- mesenchymal transition (EMT) are described. In embodiments, such compositions comprise albumin and either i) no pro-EMT agent or a low concentration of pro-EMT agent; ii) a content of pro-EMT agent and anti-EMT agent in a ratio of pro-EMT agent : anti-EMT agent that is from 7:3 to 0:10; or iii) both. The pro-EMT agent is octanoic acid, octanoate salt or a combination thereof. The anti-EMT agent is a C9-C14 fatty acid, a salt of C9-C14 fatty acid, a monoglyceride of C9-C14 fatty acid, a diglyceride of C9-C14 fatty acid, a triglyceride of C9-C14 fatty acid, or a combination thereof. Use of such albumin compositions for various therapeutic applications based on albumin, and more particularly for the treatment of diseases or conditions in which EMT should be prevented or minimized. These albumin compositions can advantageously be used in combination with known active ingredients. Also, described are composition of an anti-EMT agent for use in the treatment of various therapeutic indications, and more particularly for the treatment of diseases or conditions where EMT should be prevented or minimized.
IPC 8 full level
A61K 31/20 (2006.01); A61K 31/23 (2006.01); A61K 38/38 (2006.01); A61P 7/00 (2006.01); C07K 14/765 (2006.01)
CPC (source: EP KR RU US)
A61K 9/08 (2013.01 - KR); A61K 31/20 (2013.01 - EP KR RU); A61K 31/23 (2013.01 - EP KR US); A61K 31/337 (2013.01 - KR); A61K 38/385 (2013.01 - EP KR US); A61K 45/06 (2013.01 - KR); A61P 7/00 (2018.01 - EP KR); A61P 17/02 (2018.01 - KR); A61P 35/00 (2018.01 - KR US); C07K 14/765 (2013.01 - EP); A61K 2300/00 (2013.01 - KR)
C-Set (source: EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2018115953 A1 20180628; AU 2017381449 A1 20190725; AU 2017381449 B2 20211028; BR 112019012538 A2 20191112; CA 3047523 A1 20180628; CN 110290786 A 20190927; EP 3558289 A1 20191030; IL 267208 A 20190829; JP 2020502203 A 20200123; JP 2023017017 A 20230202; KR 20190102011 A 20190902; MX 2019007255 A 20191105; MX 2021014561 A 20220111; PH 12019501372 A1 20200120; RU 2019122735 A 20210122; RU 2019122735 A3 20210531; RU 2764630 C2 20220119; TW 201825110 A 20180716; US 2021128694 A1 20210506; US 2023346893 A1 20231102; ZA 201904558 B 20201223
DOCDB simple family (application)
IB 2017001593 W 20171220; AU 2017381449 A 20171220; BR 112019012538 A 20171220; CA 3047523 A 20171220; CN 201780086385 A 20171220; EP 17835492 A 20171220; IL 26720819 A 20190610; JP 2019533366 A 20171220; JP 2022196472 A 20221208; KR 20197020976 A 20171220; MX 2019007255 A 20171220; MX 2021014561 A 20190618; PH 12019501372 A 20190614; RU 2019122735 A 20171220; TW 106144869 A 20171220; US 201716472627 A 20171220; US 202318132517 A 20230410; ZA 201904558 A 20190711