EP 3563863 A1 20191106 - LYOPHILIZED PREPARATION
Title (en)
LYOPHILIZED PREPARATION
Title (de)
LYOPHILISIERTES PRÄPARAT
Title (fr)
PRÉPARATION LYOPHILISÉE
Publication
Application
Priority
- JP 2016257060 A 20161228
- JP 2017047207 W 20171228
Abstract (en)
[Problem] To provide a pharmaceutical composition containing a fusion protein comprising an antibody and a lysosomal enzyme as an active ingredient, which is stable enough to permit its distribution to the market.[Solution] A lyophilized formulation containing; a fusion protein comprising an antibody and a lysosomal enzyme as an active ingredient, and further containing a neutral salt, a disaccharide, a nonionic surfactant, and a buffer. Such a lyophilized formulation includes, for example, as an active ingredient, a fusion protein comprising an anti-transferrin receptor antibody and human iduronate-2-sulfatase, and further containing sodium chloride as the neutral salt, sucrose as the disaccharide, poloxamer as the nonionic surfactant, and phosphate buffer as the buffer.
IPC 8 full level
A61K 38/46 (2006.01); A61K 9/19 (2006.01); A61K 39/395 (2006.01); A61K 47/02 (2006.01); A61K 47/10 (2017.01); A61K 47/26 (2006.01); A61P 25/00 (2006.01)
CPC (source: EP KR US)
A61K 9/19 (2013.01 - EP KR US); A61K 38/00 (2013.01 - KR); A61K 38/46 (2013.01 - KR); A61K 38/465 (2013.01 - US); A61K 39/395 (2013.01 - KR); A61K 39/39591 (2013.01 - EP); A61K 47/02 (2013.01 - KR US); A61K 47/10 (2013.01 - KR US); A61K 47/26 (2013.01 - EP KR US); A61K 47/34 (2013.01 - KR US); A61P 25/00 (2017.12 - EP KR); C07K 14/70503 (2013.01 - US); C07K 16/28 (2013.01 - US); C07K 16/2881 (2013.01 - EP); C12Y 301/06013 (2013.01 - US); A61K 38/00 (2013.01 - EP); C07K 2317/24 (2013.01 - EP); C07K 2317/92 (2013.01 - EP); C07K 2319/00 (2013.01 - EP); C07K 2319/33 (2013.01 - EP)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3563863 A1 20191106; EP 3563863 A4 20201014; EP 3563863 B1 20230712; AU 2017386888 A1 20190627; BR 112019013202 A2 20191210; CA 3048381 A1 20180705; CN 110114078 A 20190809; CN 110114078 B 20240130; JP 2022078290 A 20220524; JP 7042220 B2 20220325; JP WO2018124277 A1 20191031; KR 102471458 B1 20221125; KR 20190102012 A 20190902; MX 2019007824 A 20190909; US 10940185 B2 20210309; US 2019336586 A1 20191107; US 2021187082 A1 20210624; WO 2018124277 A1 20180705
DOCDB simple family (application)
EP 17888295 A 20171228; AU 2017386888 A 20171228; BR 112019013202 A 20171228; CA 3048381 A 20171228; CN 201780081034 A 20171228; JP 2017047207 W 20171228; JP 2018559632 A 20171228; JP 2022039459 A 20220314; KR 20197021234 A 20171228; MX 2019007824 A 20171228; US 201716474307 A 20171228; US 202117181066 A 20210222