EP 3565562 A4 20200826 - DRUG COMBINATION TREATMENTS USING BONE-TARGETING THERAPEUTICS FOR BONE AND BONE-RELATED DISEASE
Title (en)
DRUG COMBINATION TREATMENTS USING BONE-TARGETING THERAPEUTICS FOR BONE AND BONE-RELATED DISEASE
Title (de)
ARZNEIMITTELKOMBINATIONSTHERAPIEN MIT AUF KNOCHEN ABZIELENDEN THERAPEUTIKA ZUR BEHANDLUNG VON KNOCHEN- UND KNOCHENASSOZIIERTEN ERKRANKUNGEN
Title (fr)
TRAITEMENTS DE POLYTHÉRAPIE UTILISANT DES AGENTS THÉRAPEUTIQUES CIBLANT LES OS POUR DES MALADIES OSSEUSES ET LIÉES AUX OS
Publication
Application
Priority
- US 201762442806 P 20170105
- US 2018012693 W 20180105
Abstract (en)
[origin: WO2018129399A1] Provided herein is a novel method for creating fixed, non-antagonistic molar ratios of drugs in and around the bone environment for desired periods of time. This method enables treating bone and bone-related disease by administering a pharmaceutical composition comprising a bone-targeted therapeutic agent able to release a drug payload from the bone surface, in addition to a second therapeutic agent. Such methods are useful in the treatment of bone and bone-related diseases, such as cancer-induced bone disease, osteomyelitis and bone infection, bone pain and inflammatory bone disease, metabolic disease, as well as others.
IPC 8 full level
A61K 31/675 (2006.01); A61K 31/337 (2006.01); A61K 31/7068 (2006.01); A61P 19/08 (2006.01); A61P 35/04 (2006.01)
CPC (source: EP US)
A61K 31/337 (2013.01 - EP US); A61K 31/7068 (2013.01 - EP US); A61K 51/0491 (2013.01 - US); A61P 19/08 (2017.12 - EP US); A61P 35/04 (2017.12 - EP US)
C-Set (source: EP)
Citation (search report)
- [Y] US 2009227544 A1 20090910 - KARPEISKY ALEXANDER [US], et al
- [Y] K. M. LEU ET AL: "Laboratory and Clinical Evidence of Synergistic Cytotoxicity of Sequential Treament With Gemcitabine Followed by Docetaxel in the Treatment of Sarcoma", JOURNAL OF CLINICAL ONCOLOGY, vol. 22, no. 9, 29 April 2004 (2004-04-29), US, pages 1706 - 1712, XP055289437, ISSN: 0732-183X, DOI: 10.1200/JCO.2004.08.043
- See references of WO 2018129399A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018129399 A1 20180712; AU 2018206453 A1 20190725; CA 3049247 A1 20180712; CN 110366417 A 20191022; EP 3565562 A1 20191113; EP 3565562 A4 20200826; EP 3565562 B1 20230628; IL 267716 A 20190829; JP 2020503365 A 20200130; RU 2019120278 A 20210206; RU 2019120278 A3 20210311; US 11324767 B2 20220510; US 2019350958 A1 20191121; US 2022323474 A1 20221013
DOCDB simple family (application)
US 2018012693 W 20180105; AU 2018206453 A 20180105; CA 3049247 A 20180105; CN 201880014320 A 20180105; EP 18736682 A 20180105; IL 26771619 A 20190630; JP 2019537137 A 20180105; RU 2019120278 A 20180105; US 201816476043 A 20180105; US 202217725237 A 20220420