EP 3567043 B1 20231206 - 2-[[5-[(4-HYDROXY-3-CHLORO-2-METHYL)-PHENYL]-THIENO[2,3-D]PYRIMIDIN-4-YL]OXY]-3-(2-METHOXYBENZENE)PROPANOIC ACID DERIVATIVES AS MCL-1 AND BCL-2 INHIBITORS FOR TREATING CANCER
Title (en)
2-[[5-[(4-HYDROXY-3-CHLORO-2-METHYL)-PHENYL]-THIENO[2,3-D]PYRIMIDIN-4-YL]OXY]-3-(2-METHOXYBENZENE)PROPANOIC ACID DERIVATIVES AS MCL-1 AND BCL-2 INHIBITORS FOR TREATING CANCER
Title (de)
2-[[5-[(4-HYDROXY-3-CHLORO-2-METHYL)-PHENYL]-THIENO[2,3-D]PYRIMIDIN-4-YL]OXY]-3-(2-METHOXYBENZEN)PROPANSÄURE-DERIVATE ALS MCL-1 UND BCL-2 INHIBITOREN ZUR BEHANDLUNG VON KREBS
Title (fr)
DÉRIVÉS DU ACIDE PROPANOÏQUE 2-[[5-[(4-HYDROXY-3-CHLORO-2-MÉTHYL)-PHÉNYL]-THIÉNO[2,3-D]PYRIMIDIN-4-YL]OXY]-3-(2-MÉTHOXYBENZENE) EN TANT QU'INHIBITEURS MCL-1 ET BCL-2 POUR LE TRAITEMENT DU CANCER
Publication
Application
Priority
- CN 201710006807 A 20170105
- CN 2017117610 W 20171221
Abstract (en)
[origin: EP3567043A1] The present invention provides a thienopyrimidinone derivative, a preparation method thereof, and an application thereof in manufacturing of antitumor drugs. The derivative has a structure as represented by general formula (I), comprising a single stereoisomer or racemic mixture thereof, wherein R is independently selected from hydrogen (H) or deuterium (D); R<sup>1</sup>and R<sup>2</sup>independently, at each occurrence, represent H, D, F, Cl, I, cyano group (CN), or N<sub>3</sub>, and when R represents H, R<sup>1</sup>and R<sup>2</sup>do not synchronously represent H; R<sup>3</sup>, R<sup>4</sup>and R<sup>5</sup>independently, at each occurrence, represent an alkyl group, a cycloalkyl group, a heterocyclic group, an aromatic ring group, or a heteroaryl ring group, which are substituted or unsubstituted.
IPC 8 full level
C07D 495/04 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP US); C07D 495/04 (2013.01 - EP US); A61K 45/06 (2013.01 - US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3567043 A1 20191113; EP 3567043 A4 20201202; EP 3567043 B1 20231206; EP 3567043 C0 20231206; US 10919908 B2 20210216; US 2019330230 A1 20191031; WO 2018126898 A1 20180712
DOCDB simple family (application)
EP 17889767 A 20171221; CN 2017117610 W 20171221; US 201916503656 A 20190705