EP 3568162 A1 20191120 - MULTI-ARM POLYMER CONJUGATES OF TLR AGONIST COMPOUNDS AND RELATED IMMUNOTHERAPEUTIC TREATMENT METHODS
Title (en)
MULTI-ARM POLYMER CONJUGATES OF TLR AGONIST COMPOUNDS AND RELATED IMMUNOTHERAPEUTIC TREATMENT METHODS
Title (de)
MEHRARMIGE POLYMERKONJUGATE VON TLR-AGONISTENVERBINDUNGEN UND VERWANDTE IMMUNOTHERAPEUTISCHE BEHANDLUNGSVERFAHREN
Title (fr)
CONJUGUÉS POLYMÈRES À BRAS MULTIPLES DE COMPOSÉS AGONISTES DE TLR ET MÉTHODES DE TRAITEMENT IMMUNOTHÉRAPEUTIQUES ASSOCIÉES
Publication
Application
Priority
- US 201762444735 P 20170110
- US 201762444756 P 20170110
- US 201762467945 P 20170307
- US 201762488407 P 20170421
- US 201762488251 P 20170421
- US 201762510019 P 20170523
- US 201762510024 P 20170523
- US 2018013199 W 20180110
Abstract (en)
[origin: WO2018132496A1] Provided are multi-arm polymer conjugates of Toll-Like Receptor ("TLR") agonists such as TLR 7/8 agonists, as well as related compositions, and methods of making and using such conjugates. Exemplary conjugates are encompassed by Formula I: (I) or a pharmaceutically acceptable salt form thereof, where R, taken together with each Q, is a residue of a polyol, polythiol, or polyamine bearing from 3 to about 50 hydroxyl, thiol, or amino groups; each Q is a linker selected from oxygen, sulfur and -NH; each POLY is independently a water-soluble, non-peptidic polymer; each Xr is independently a linkage-containing spacer moiety; q is a positive integer from 3 to about 50; and each TLR 7/8 AG is a Toll-like receptor 7/8 agonist. Also provided is a method of administering to a patient having cancer (a) an IL-2Rβ-activating amount of a long-acting, IL-2Rβ-selective agonist; and (b) a Toll-like receptor agonist such as a conjugate as described above, as well as related compositions, kits and methods.
IPC 8 full level
A61K 47/60 (2017.01); A61P 35/00 (2006.01)
CPC (source: EP IL KR US)
A61K 9/0029 (2013.01 - IL US); A61K 31/4745 (2013.01 - IL KR); A61K 31/501 (2013.01 - IL KR); A61K 47/54 (2017.08 - IL US); A61K 47/60 (2017.08 - EP IL KR US); A61K 47/642 (2017.08 - IL US); A61P 35/00 (2018.01 - EP IL KR US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2018132496 A1 20180719; AU 2018207283 A1 20190718; AU 2018207283 A2 20190725; AU 2018207283 B2 20240215; AU 2018207283 C1 20240502; CA 3049254 A1 20180719; CN 110167598 A 20190823; EP 3568162 A1 20191120; IL 267929 A 20190926; IL 267929 B 20221101; IL 267929 B2 20230301; IL 297655 A 20221201; JP 2020514300 A 20200521; JP 2023071870 A 20230523; JP 7250679 B2 20230403; KR 102619747 B1 20231229; KR 20190104377 A 20190909; MX 2019008276 A 20190916; US 11744898 B2 20230905; US 2021128737 A1 20210506; US 2023372500 A1 20231123
DOCDB simple family (application)
US 2018013199 W 20180110; AU 2018207283 A 20180110; CA 3049254 A 20180110; CN 201880006411 A 20180110; EP 18705743 A 20180110; IL 26792919 A 20190708; IL 29765522 A 20221025; JP 2019537064 A 20180110; JP 2023032182 A 20230302; KR 20197023021 A 20180110; MX 2019008276 A 20180110; US 201816475972 A 20180110; US 202318221300 A 20230712