EP 3575325 A4 20201223 - MULTI-TARGET CHIMERIC ANTIGEN RECEPTOR
Title (en)
MULTI-TARGET CHIMERIC ANTIGEN RECEPTOR
Title (de)
CHIMÄRER ANTIGENREZEPTOR MIT MEHREREN TARGETS
Title (fr)
RÉCEPTEUR D'ANTIGÈNE CHIMÉRIQUE MULTI-CIBLES
Publication
Application
Priority
- CN 201611246563 A 20161229
- CN 2017118980 W 20171227
Abstract (en)
[origin: EP3575325A1] Disclosed in the present invention is a multi-target chimeric antigen receptor. Provided in the present invention is a multi-target chimeric antigen receptor consisting of a main peptide chain and an auxiliary peptide chain; the main peptide chain comprises an antigen binding domain A, an auxiliary peptide chain connecting domain B, a transmembrane domain C and an intracellular signaling domain D; the auxiliary peptide chain comprises a main peptide chain connecting domain F; the antigen binding domain A is a polypeptide having an antigen-binding function; the auxiliary chain connecting domain B and the main peptide connecting domain F are combined with each other; the transmembrane domain C is a transmembrane domain of any membrane-binding protein or a transmembrane protein; and the intracellular signaling domain D comprises a primary signaling region. The multi-target chimeric antigen receptor of the present invention can bind to different antigens through the two antigen binding domains thereof, and mediates specific cell killing; and a cytokine and cytokine receptor complex playing the role of a cytokine are introduced into the multi-target chimeric antigen receptor of the present invention.
IPC 8 full level
C07K 19/00 (2006.01); A61K 35/17 (2015.01); A61P 35/00 (2006.01); C07K 14/725 (2006.01); C12N 5/10 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01); G01N 33/68 (2006.01)
CPC (source: CN EP US)
A61K 39/4611 (2023.05 - CN EP US); A61K 39/4613 (2023.05 - CN EP US); A61K 39/4631 (2023.05 - CN EP US); A61K 39/464411 (2023.05 - CN EP US); A61K 39/464412 (2023.05 - CN EP US); A61K 39/464453 (2023.05 - CN EP US); A61K 39/464492 (2023.05 - CN EP US); A61K 2239/29 (2023.05 - US); A61P 35/00 (2018.01 - EP); C07K 14/705 (2013.01 - CN); C07K 14/7051 (2013.01 - EP US); C07K 14/715 (2013.01 - CN US); C07K 16/00 (2013.01 - CN); C07K 16/30 (2013.01 - CN); C07K 19/00 (2013.01 - EP); C12N 5/0634 (2013.01 - CN EP US); C12N 5/0636 (2013.01 - CN EP US); C12N 5/0646 (2013.01 - CN EP US); C12N 5/10 (2013.01 - EP); C12N 15/62 (2013.01 - EP); C12N 15/63 (2013.01 - EP US); G01N 33/68 (2013.01 - CN EP); A61K 2239/29 (2023.05 - CN EP); C07K 2319/02 (2013.01 - CN); C07K 2319/03 (2013.01 - CN EP)
Citation (search report)
- [I] WO 2013123061 A1 20130822 - SEATTLE CHILDREN S HOSPITAL D B A SEATTLE CHILDREN S RES INST [US]
- [I] WO 2012040323 A2 20120329 - ALTOR BIOSCIEN CORP [US], et al
- [A] WO 2014186469 A2 20141120 - UNIV TEXAS [US]
- [A] WO 2012175222 A1 20121227 - CYTUNE [FR], et al
- [A] CHRISTIANE SAHM ET AL: "Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor", CANCER IMMUNOLOGY, IMMUNOTHERAPY, SPRINGER, BERLIN, DE, vol. 61, no. 9, 5 February 2012 (2012-02-05), pages 1451 - 1461, XP035103279, ISSN: 1432-0851, DOI: 10.1007/S00262-012-1212-X
- See also references of WO 2018121604A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3575325 A1 20191204; EP 3575325 A4 20201223; CN 108250301 A 20180706; CN 109153730 A 20190104; CN 109153730 B 20220405; JP 2020515282 A 20200528; US 2022064595 A1 20220303; WO 2018121604 A1 20180705
DOCDB simple family (application)
EP 17886078 A 20171227; CN 201611246563 A 20161229; CN 2017118980 W 20171227; CN 201780029218 A 20171227; JP 2019556410 A 20171227; US 201716475030 A 20171227