EP 3581190 A1 20191218 - ENGINEERED NATURAL KILLER CELLS AND USES THEREOF

Title (en)

ENGINEERED NATURAL KILLER CELLS AND USES THEREOF

Title (de)

MANIPULIERTE NATÜRLICHE KILLERZELLEN UND VERWENDUNGEN DAVON

Title (fr)

CELLULES TUEUSES NATURELLES MODIFIÉES ET LEURS UTILISATIONS

Publication

EP 3581190 A1 20191218 (EN)

Application

EP 19176141 A 20171211

Priority

US 201662432302 P 20161209
EP 17825774 A 20171211
EP 2017082292 W 20171211

Abstract (en)

Natural killer cells are modified to express chimeric antigen receptors (CARs) for CD38. The cells can contain other modifications that improve tumor specific cytotoxicity and homing to tumor sites, e.g. expression of mutant TRAIL. Methods for using the engineered natural killer cells, e.g. to treat patients with cancer, are provided.

IPC 8 full level

A61K 35/15 (2015.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01)

CPC (source: CN EP KR US)

A61K 35/15 (2013.01 - KR); A61K 38/177 (2013.01 - EP KR US); A61K 39/0011 (2013.01 - KR); A61K 39/001126 (2018.08 - CN); A61K 39/4613 (2023.05 - EP US); A61K 39/4631 (2023.05 - EP US); A61K 39/4636 (2023.05 - EP US); A61K 39/464426 (2023.05 - EP US); A61K 2239/38 (2023.05 - US); A61K 2239/46 (2023.05 - US); A61K 2239/48 (2023.05 - US); A61P 35/00 (2018.01 - CN EP KR US); C07K 14/7051 (2013.01 - CN); C07K 16/2896 (2013.01 - CN EP US); C12N 5/0646 (2013.01 - CN EP KR US); A61K 2035/124 (2013.01 - US); A61K 2039/505 (2013.01 - US); A61K 2039/5156 (2013.01 - CN KR); A61K 2039/5158 (2013.01 - KR); A61K 2039/804 (2018.08 - CN); A61K 2239/38 (2023.05 - EP); A61K 2239/46 (2023.05 - EP); A61K 2239/48 (2023.05 - EP); C07K 2317/56 (2013.01 - CN US); C07K 2317/565 (2013.01 - CN US); C07K 2317/622 (2013.01 - EP); C07K 2319/03 (2013.01 - CN); C07K 2319/33 (2013.01 - CN); C07K 2319/70 (2013.01 - US); C07K 2319/74 (2013.01 - CN); C12N 2510/00 (2013.01 - CN KR)

Citation (applicant)

WO 2009077857 A2 20090625 - FUNDACIO PRIVADA CT DE REGULAC [ES], et al
WO 2011154453 A1 20111215 - GENMAB AS [DK], et al
WO 2006099875 A1 20060928 - GENMAB AS [DK], et al
YAGITA ET AL.: "A novel natural killer cell line (KHYG-1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation", LEUKEMIA, vol. 14, no. 5, pages 922 - 30, XP055510744, DOI: doi:10.1038/sj.leu.2401769

Citation (search report)

[A] E. DRENT ET AL: "Pre-clinical evaluation of CD38 chimeric antigen receptor engineered T cells for the treatment of multiple myeloma", HAEMATOLOGICA, THE HEMATOLOGY JOURNAL : OFFICIAL ORGAN OF THE EUROPEAN HEMATOLOGY ASSOCIATION, vol. 101, no. 5, 8 February 2016 (2016-02-08), IT, pages 616 - 625, XP055460439, ISSN: 0390-6078, DOI: 10.3324/haematol.2015.137620
[A] HANS KLINGEMANN: "Are natural killer cells superior CAR drivers?", ONCOIMMUNOLOGY, vol. 3, no. 1, 1 January 2014 (2014-01-01), pages e28147, XP055145390, ISSN: 2162-4011, DOI: 10.4161/onci.28147
[A] SHIHONG YANG ET AL: "Development of Retargeted CD38-Specific NK-92 Cell Line for Potential Anti-Myeloma Immunotherapy. | Blood Journal", BLOOD 106, 1 January 2005 (2005-01-01), pages 5104, XP055460459, Retrieved from the Internet <URL:http://www.bloodjournal.org/content/106/11/5104> [retrieved on 20180319]
[A] J CHU ET AL: "CS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma", LEUKEMIA, vol. 28, no. 4, 26 September 2013 (2013-09-26), pages 917 - 927, XP055133640, ISSN: 0887-6924, DOI: 10.1038/leu.2013.279

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

US 10799536 B2 20201013; US 2018161371 A1 20180614; AU 2017371517 A1 20190704; AU 2017371517 B2 20230105; BR 112019011450 A2 20191015; CA 3045386 A1 20180614; CN 110248669 A 20190917; CN 110248669 B 20230908; CN 117305250 A 20231229; DK 3454871 T3 20190916; DK 3581190 T3 20210607; EP 3454871 A1 20190320; EP 3454871 B1 20190626; EP 3581190 A1 20191218; EP 3581190 B1 20210310; EP 3895712 A1 20211020; EP 3895712 B1 20220622; EP 4104841 A1 20221221; ES 2746856 T3 20200309; ES 2875005 T3 20211108; ES 2926397 T3 20221026; JP 2020503891 A 20200206; JP 2023052980 A 20230412; JP 7228900 B2 20230227; KR 20190114966 A 20191010; MX 2019006598 A 20191015; RU 2019121509 A 20210111; RU 2019121509 A3 20210330; US 2021046118 A1 20210218; WO 2018104562 A1 20180614

DOCDB simple family (application)

US 201715837576 A 20171211; AU 2017371517 A 20171211; BR 112019011450 A 20171211; CA 3045386 A 20171211; CN 201780085686 A 20171211; CN 202311063691 A 20171211; DK 17825774 T 20171211; DK 19176141 T 20171211; EP 17825774 A 20171211; EP 19176141 A 20171211; EP 2017082292 W 20171211; EP 21160170 A 20171211; EP 22179362 A 20171211; ES 17825774 T 20171211; ES 19176141 T 20171211; ES 21160170 T 20171211; JP 2019551736 A 20171211; JP 2023017202 A 20230207; KR 20197019363 A 20171211; MX 2019006598 A 20171211; RU 2019121509 A 20171211; US 202017008506 A 20200831