EP 3585389 A1 20200101 - TREATMENT OF EGFR-DRIVEN CANCER WITH FEWER SIDE EFFECTS
Title (en)
TREATMENT OF EGFR-DRIVEN CANCER WITH FEWER SIDE EFFECTS
Title (de)
BEHANDLUNG VON EGFR-VERMITTELTEM KREBS MIT WENIGER NEBENWIRKUNGEN
Title (fr)
TRAITEMENT DU CANCER ENTRAÎNÉ PAR EGFR AVEC MOINS D'EFFETS SECONDAIRES
Publication
Application
Priority
- US 201762462094 P 20170222
- US 2018019291 W 20180222
Abstract (en)
[origin: WO2018156812A1] The present invention provides methods for treating a EGFR-mutant cancer in a patient by administering a selective CDK4/6 inhibitor described herein in combination or alternation with an EGFR-TKI to delay or reverse acquired resistance to previously administered EGFR-TKIs. In addition, methods for treating a EGFR-mutant cancer in a patient by administering a selective CDK4/6 inhibitor described herein in combination or alternation with an EGFR-TKI are provided wherein an intrinsically EGFR-TKI resistant EGFR-mutant cancer is sensitized to the effects of the EGFR-TKI.
IPC 8 full level
A61K 31/495 (2006.01); A61K 31/519 (2006.01); C07D 487/14 (2006.01)
CPC (source: EP US)
A61K 31/4709 (2013.01 - US); A61K 31/506 (2013.01 - EP US); A61K 31/517 (2013.01 - US); A61K 31/519 (2013.01 - US); A61K 31/527 (2013.01 - EP); A61K 31/5377 (2013.01 - US); A61P 35/00 (2017.12 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2018156812 A1 20180830; CN 110325191 A 20191011; EP 3585389 A1 20200101; EP 3585389 A4 20201223; US 2023146638 A1 20230511
DOCDB simple family (application)
US 2018019291 W 20180222; CN 201880013231 A 20180222; EP 18758002 A 20180222; US 202217854755 A 20220630