Global Patent Index - EP 3590961 A1

EP 3590961 A1 20200108 - BISPECIFIC MULTIVALENT FUSION PROTEINS

Title (en)

BISPECIFIC MULTIVALENT FUSION PROTEINS

Title (de)

BISPEZIFISCHE MULTIVALENTE FUSIONSPROTEINE

Title (fr)

PROTÉINES DE FUSION BISPÉCIFIQUES MULTIVALENTES

Publication

EP 3590961 A1 20200108 (EN)

Application

EP 19189394 A 20151216

Priority

  • US 201562138003 P 20150325
  • EP 15823452 A 20151216
  • US 2015066131 W 20151216

Abstract (en)

The invention provides a construct comprising two or more fusion proteins of Formulas (I)-(IV): A-(optional linker)-C-(optional linker)-B (Formula I), B-(optional linker)-D-(optional linker)-E-(optional linker)-B (Formula II), A-(optional linker)-C (Formula III), and B-(optional linker)-D-(optional linker)-E (Formula IV), wherein A denotes an antibody or antibody fragment, B denotes a single domain CD4, C denotes an immunoglobulin light chain constant region, D denotes an immunoglobulin heavy chain constant region, and E denotes an Fc region or a portion thereof that is optionally defucosylated.

IPC 8 full level

C07K 16/10 (2006.01); A61K 38/00 (2006.01); A61K 38/16 (2006.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01); A61P 31/18 (2006.01); C07K 14/435 (2006.01); C07K 14/73 (2006.01)

CPC (source: EP US)

A61P 31/18 (2018.01 - EP US); C07K 14/70514 (2013.01 - EP US); C07K 16/1063 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/14 (2013.01 - EP US); C07K 2317/21 (2013.01 - EP US); C07K 2317/31 (2013.01 - EP US); C07K 2317/35 (2013.01 - US); C07K 2317/41 (2013.01 - EP US); C07K 2317/515 (2013.01 - EP US); C07K 2317/522 (2013.01 - EP US); C07K 2317/526 (2013.01 - EP US); C07K 2317/53 (2013.01 - US); C07K 2317/569 (2013.01 - EP US); C07K 2317/72 (2013.01 - EP US); C07K 2317/732 (2013.01 - EP US); C07K 2317/76 (2013.01 - EP US); C07K 2317/90 (2013.01 - EP US); C07K 2317/92 (2013.01 - EP US); C07K 2317/94 (2013.01 - EP US); C07K 2319/00 (2013.01 - EP US); C07K 2319/30 (2013.01 - EP US); C07K 2319/32 (2013.01 - EP US); C07K 2319/33 (2013.01 - EP US)

Citation (applicant)

  • WO 2014150748 A2 20140925 - US HEALTH [US]
  • WO 2008077546 A1 20080703 - HOFFMANN LA ROCHE [CH], et al
  • US 2003157108 A1 20030821 - PRESTA LEONARD G [US]
  • US 2004093621 A1 20040513 - SHITARA KENYA [JP], et al
  • US 2003115614 A1 20030619 - KANDA YUTAKA [JP], et al
  • US 2002164328 A1 20021107 - SHINKAWA TOYOHIDE [JP], et al
  • US 2004132140 A1 20040708 - SATOH MITSUO [JP], et al
  • US 2004110704 A1 20040610 - YAMANE NAOKO [JP], et al
  • US 2004110282 A1 20040610 - KANDA YUTAKA [JP], et al
  • US 2004109865 A1 20040610 - NIWA RINPEI [JP], et al
  • WO 0061739 A1 20001019 - KYOWA HAKKO KOGYO KK [JP], et al
  • WO 0129246 A1 20010426 - KYOWA HAKKO KOGYO KK [JP], et al
  • WO 03085119 A1 20031016 - KYOWA HAKKO KOGYO KK [JP], et al
  • WO 03084570 A1 20031016 - KYOWA HAKKO KOGYO KK [JP], et al
  • WO 2005035586 A1 20050421 - KYOWA HAKKO KOGYO KK [JP], et al
  • WO 2005035778 A1 20050421 - KYOWA HAKKO KOGYO KK [JP], et al
  • WO 2005053742 A1 20050616 - KYOWA HAKKO KOGYO KK [JP], et al
  • WO 0231140 A1 20020418 - KYOWA HAKKO KOGYO KK [JP]
  • WO 2004056312 A2 20040708 - GENENTECH INC [US], et al
  • WO 03085107 A1 20031016 - KYOWA HAKKO KOGYO KK [JP], et al
  • US 6015876 A 20000118 - BOYD MICHAEL R [US]
  • US 7491798 B2 20090217 - BOYD MICHAEL R [US], et al
  • US 2009092557 A1 20090409 - BOYD MICHAEL R [US], et al
  • OKAZAKI ET AL., J. MOL. BIOL., vol. 336, 2004, pages 1239 - 1249
  • YAMANE-OHNUKI ET AL., BIOTECH. BIOENG., vol. 87, 2004, pages 614
  • RIPKA ET AL., ARCH. BIOCHEM. BIOPHYS., vol. 249, 1986, pages 533 - 545
  • KANDA ET AL., BIOTECHNOL. BIOENG., vol. 94, no. 4, 2006, pages 680 - 688
  • WILSON ET AL., CELL, vol. 37, 1984, pages 767
  • DAVIS ET AL., BASIC METHODS IN MOLECULAR BIOLOGY, 1986
  • NEUMANN ET AL., EMBO J., vol. 1, 1982, pages 841
  • SCHOONJAN ET AL., J. IMMUNOL., vol. 165, 2000, pages 7050 - 7057
  • ANDREU ET AL., J. INFECT. DIS., vol. 171, no. 5, 1995, pages 1237 - 43
  • SILVESTRI ET AL.: "Immunology of Infectious Disease", 2002, ASM PRESS, article "Immune Intervention in AIDS"
  • CHEN ET AL., J. VIROL., vol. 85, 2011, pages 9395 - 405
  • CHEN ET AL., J. VIROL., vol. 88, 2014, pages 1125 - 39
  • FENG ET AL., PROTEIN EXPR. PURIF., vol. 79, 2011, pages 66 - 71
  • CHEN ET AL., J. MOL. BIOL., vol. 382, 2008, pages 779 - 89
  • ZHU ET AL., J. VIROL., vol. 80, 2006, pages 891 - 9
  • CHEN ET AL., MOL. IMMUNOL., vol. 47, 2010, pages 912 - 21
  • GARDNER ET AL., NATURE, vol. 519, 2015, pages 87 - 91
  • CHEN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 105, 2008, pages 17121 - 6
  • ZHU ET AL., MABS, vol. 6, 2014, pages 1190 - 200
  • MULLER ET AL., FEBSLETT., vol. 422, 1998, pages 259 - 264
  • ROZAN ET AL., MOL. CANCER THER., vol. 12, 2013, pages 1481 - 1491
  • MULLER ET AL., FEBS LETT., vol. 422, 1998, pages 259 - 264
  • ALLAWAY ET AL., AIDS RES. HUM. RETROVIRUSES, vol. 11, 1995, pages 533 - 9
  • ROTHLISBERGER ET AL., J. MOL. BIOL., vol. 347, 2005, pages 773 - 89
  • CHEN ET AL., ANTIVIRAL RES., vol. 88, 2010, pages 107 - 15
  • KO ET AL., NATURE, vol. 514, 2014, pages 642 - 5
  • ZALEVSKY ET AL., NAT. BIOTECHNOL., vol. 28, 2010, pages 157 - 9
  • LEWIS ET AL., IMMUNOLOGY, vol. 142, 2014, pages 46 - 57
  • BOURNAZOS ET AL., CELL, vol. 158, 2014, pages 1243 - 53
  • MOLDT ET AL., J. VIROL., vol. 86, 2012, pages 189 - 96

Citation (search report)

  • [Y] WO 2014150748 A2 20140925 - US HEALTH [US]
  • [Y] WO 2011146891 A2 20111124 - US HEALTH [US], et al
  • [A] WO 2006089232 A2 20060824 - MEDAREX INC [US], et al
  • [A] WO 2013026831 A1 20130228 - ROCHE GLYCART AG [CH], et al
  • [A] WO 03035835 A2 20030501 - GENENTECH INC [US]
  • [Y] WO 2014081955 A1 20140530 - AMGEN INC [US]
  • [Y] WO 2014082179 A1 20140605 - ZYMEWORKS INC [CA]
  • [A] WO 2013012733 A1 20130124 - BIOGEN IDEC INC [US], et al
  • [A] W. CHEN ET AL: "Engineered Single Human CD4 Domains as Potent HIV-1 Inhibitors and Components of Vaccine Immunogens", JOURNAL OF VIROLOGY, vol. 85, no. 18, 29 June 2011 (2011-06-29), pages 9395 - 9405, XP055123743, ISSN: 0022-538X, DOI: 10.1128/JVI.05119-11
  • [A] RINPEI NIWA ET AL: "The Current Status and Prospects of Antibody Engineering for Therapeutic Use: Focus on Glycoengineering Technology", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 104, no. 3, 12 January 2015 (2015-01-12), WASHINGTON, US, pages 930 - 941, XP055219479, ISSN: 0022-3549, DOI: 10.1002/jps.24316
  • [A] YARIV MAZOR ET AL: "Improving target cell specificity using a novel monovalent bispecific IgG design", MABS, vol. 7, no. 2, 1 January 2015 (2015-01-01), US, pages 377 - 389, XP055218393, ISSN: 1942-0870, DOI: 10.1080/19420862.2015.1007816
  • [A] MULLER K M ET AL: "The first constant domain (C"H1 and C"L) of an antibody used as heterodimerization domain for bispecific miniantibodies", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 422, no. 2, 30 January 1998 (1998-01-30), pages 259 - 264, XP004261818, ISSN: 0014-5793, DOI: 10.1016/S0014-5793(98)00021-0
  • [A] SCHOONJANS R ET AL: "A new model for intermediate molecular weight recombinant bispecific and trispecific antibodies by efficient heterodimerization of single chain variable domains through fusion to a Fab-chain", BIOMOLECULAR ENGINEERING, ELSEVIER, NEW YORK, NY, US, vol. 17, no. 6, 1 June 2001 (2001-06-01), pages 193 - 202, XP002207880, ISSN: 1389-0344, DOI: 10.1016/S1389-0344(01)00066-1

Citation (examination)

DIETMAR REUSCH ET AL: "Fc glycans of therapeutic antibodies as critical quality attributes", GLYCOBIOLOGY, vol. 25, no. 12, 11 August 2015 (2015-08-11), US, pages 1325 - 1334, XP055425665, ISSN: 0959-6658, DOI: 10.1093/glycob/cwv065

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2016153572 A1 20160929; EP 3274368 A1 20180131; EP 3590961 A1 20200108; US 10472412 B2 20191112; US 2018118815 A1 20180503

DOCDB simple family (application)

US 2015066131 W 20151216; EP 15823452 A 20151216; EP 19189394 A 20151216; US 201515561268 A 20151216