Global Patent Index - EP 3597223 A1

EP 3597223 A1 20200122 - PEPTIDES FOR USE AS CELL-PENETRATING PEPTIDES

Title (en)

PEPTIDES FOR USE AS CELL-PENETRATING PEPTIDES

Title (de)

PEPTIDE ZUR VERWENDUNG ALS ZELLENPENETRIERENDE PEPTIDE

Title (fr)

PEPTIDES POUR UTILISATION EN TANT QUE PEPTIDES PÉNÉTRANT DES CELLULES

Publication

EP 3597223 A1 20200122 (EN)

Application

EP 18183966 A 20180717

Priority

EP 18183966 A 20180717

Abstract (en)

The present invention relates to new peptides comprising an amino acid sequence LL-[X]n-LL, wherein X is selected from R, L and W, and n= 10 to 12, and wherein [X]n comprises 4 R, 4 L and between 2 and 4 W, that may be used as cell-penetrating peptides. The present invention also relates to nanoparticles comprising a peptide of the invention and a cargo molecule and uses thereof.

IPC 8 full level

A61K 48/00 (2006.01); A61K 31/713 (2006.01); C07K 7/08 (2006.01); C12N 15/113 (2010.01)

CPC (source: EP US)

A61K 9/5169 (2013.01 - EP US); A61K 31/713 (2013.01 - EP); A61K 45/06 (2013.01 - EP); C07K 7/08 (2013.01 - EP US); C12N 15/111 (2013.01 - EP); C12N 15/1137 (2013.01 - US); C12N 15/87 (2013.01 - EP); A61K 38/00 (2013.01 - EP); C07K 2319/10 (2013.01 - EP); C12N 2310/14 (2013.01 - EP US); C12N 2320/32 (2013.01 - EP US)

C-Set (source: EP)

A61K 31/713 + A61K 2300/00

Citation (applicant)

  • A. ELMQUIST ET AL.: "VE-Cadherin-Derived Cell-Penetrating Peptide, pVEC, with Carrier Functions", EXP. CELL RES., vol. 269, 2001, pages 237 - 244, XP003013956, DOI: doi:10.1006/excr.2001.5316
  • S. DESHAYES ET AL.: "Cell-penetrating peptides: tools for intracellular delivery of therapeutics", CELL. MOL. LIFE SCI. CMLS., vol. 62, 2005, pages 1839 - 1849, XP019200807, DOI: doi:10.1007/s00018-005-5109-0
  • D. DEROSSI ET AL.: "The third helix of the Antennapedia homeodomain translocates through biological membranes", J. BIOL. CHEM., vol. 269, no. 14, 1994, pages 10444 - 50
  • M. POOGA ET AL.: "Cell penetration by transportan", FASEB J., vol. 12, 1998, pages 67 - 77
  • J. HOYER ET AL.: "Knock-down of a G protein-coupled receptor through efficient peptide-mediated siRNA delivery", J. CONTROL. RELEASE OFF. J. CONTROL. RELEASE SOC., vol. 161, no. 3, 2012, pages 826 - 834
  • A. VAISSIERE ET AL.: "A retro-inverso cell-penetrating peptide for siRNA delivery", J NANOBIOTECHNOLOGY, vol. 15, no. 1, 2017, pages 34
  • M. JAFARI ET AL.: "Serum stability and physicochemical characterization of a novel amphipathic peptide C6M 1 for siRNA delivery", PLOS ONE, vol. 9, no. 5, 2014, pages e97797
  • AUSUBEL, F.M. ET AL.: "Current Protocols in Molecular Biology", 2001, WILEY & SONS
  • KONATE K ET AL.: "Optimisation of vectorisation property: a comparative study for a secondary amphipathic peptide", INT J PHARM., vol. 509, 2016, pages 71 - 84, XP029623618, DOI: doi:10.1016/j.ijpharm.2016.05.030
  • H. KAUR ET AL., PROTEIN PEPT. LETT., vol. 14, 2007, pages 626 - 630
  • S. SINGH ET AL., BIOL. DIRECT., vol. 10, 2015, pages 73
  • G. ALDRIAN ET AL., J. CONTROL. RELEASE OFF. J. CONTROL. RELEASE SOC., vol. 256, 2017, pages 79 - 91
  • L.N. PATEL ET AL., PHARM. RES., vol. 24, 2007, pages 1977 - 1992
  • A. ELMQUIST ET AL., EXP. CELL RES., vol. 269, 2001, pages 237 - 244
  • D.W. PARSONSET: "An integrated genomic analysis of human glioblastoma multiforme", SCIENCE, vol. 321, 2008, pages 1807 - 1812
  • A. VAISSIERE ET AL.: "A retro-inverso cell-penetrating peptide for siRNA delivery", J. NANOBIOTECHNOLOGY, vol. 15, 2017, pages 34
  • G. ALDRIAN ET AL.: "PEGylation rate influences peptide-based nanoparticles mediated siRNA delivery in vitro and in vivo", J. CONTROL. RELEASE OFF. J. CONTROL. RELEASE SOC., vol. 256, 2017, pages 79 - 91
  • A. RYDSTROM ET AL.: "Direct translocation as major cellular uptake for CADY self-assembling peptide-based nanoparticles", PLOS ONE, vol. 6, 2011, pages e25924
  • F. DANHIER ET AL., MOL PHARM., vol. 9, no. 11, 2012, pages 2961 - 73
  • D.M. COPOLOVICI ET AL., ACS NANO, vol. 8, no. 3, 2014, pages 1972 - 94
  • D. AROSIO ET AL., RECENT PAT ANTICANCER DRUG DISCOV., vol. 12, no. 2, 2017, pages 148 - 168
  • U.K. MARELLI UK ET AL., FRONT ONCOL., vol. 3, 2013, pages 222
  • T. LEHTO ET AL., DRUG DELIV. REV., vol. 106, 2016, pages 172 - 182

Citation (search report)

  • [A] WO 2011020188 A1 20110224 - UNIV WATERLOO [CA], et al & DATABASE Geneseq [online] 31 March 2011 (2011-03-31), "siRNA-co-assembly/cell penetration peptide, C6.", XP002785305, retrieved from EBI accession no. GSP:AZF22135 Database accession no. AZF22135
  • [A] WO 2013075244 A1 20130530 - CHEN PU [CA], et al
  • [A] KONATE KARIDIA ET AL: "Optimisation of vectorisation property: A comparative study for a secondary amphipathic peptide", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 509, no. 1, 17 May 2016 (2016-05-17), pages 71 - 84, XP029623618, ISSN: 0378-5173, DOI: 10.1016/J.IJPHARM.2016.05.030

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

Designated extension state (EPC)

BA ME

DOCDB simple family (publication)

EP 3597223 A1 20200122; CA 3105584 A1 20200123; CN 112584873 A 20210330; EP 3823675 A1 20210526; JP 2021531274 A 20211118; US 11905338 B2 20240220; US 2021292364 A1 20210923; WO 2020016242 A1 20200123

DOCDB simple family (application)

EP 18183966 A 20180717; CA 3105584 A 20190716; CN 201980047720 A 20190716; EP 19740378 A 20190716; EP 2019069149 W 20190716; JP 2021502515 A 20190716; US 201917260244 A 20190716