EP 3601327 A1 20200205 - MODELING miRNA INDUCED SILENCING IN BREAST CANCER WITH PARADIGM
Title (en)
MODELING miRNA INDUCED SILENCING IN BREAST CANCER WITH PARADIGM
Title (de)
MODELLIERUNG VON MIRNA-INDUZIERTEM SILENCING BEI BRUSTKREBS MIT PARADIGMA
Title (fr)
MODÉLISATION DE SILENÇAGE INDUIT PAR miARN DANS LE CANCER DU SEIN AVEC PARADIGME
Publication
Application
Priority
- US 201762477929 P 20170328
- US 2018024615 W 20180327
Abstract (en)
[origin: WO2018183363A1] A probabilistic graphical pathway model is modified to include miRNA regulation by adding RISC as a regulatory factor. Most preferably, the pathway model is built using factor graphs, and the RISC includes DICER, TARBP2, and AGO2 or AGO1/3/4. So constructed pathway models can be used to infer RISC activity, which can be associated with various clinically relevant parameters to build various predictors or diagnostic tests.
IPC 8 full level
C07K 14/47 (2006.01); C12Q 1/68 (2018.01); G01N 33/48 (2006.01); G16B 5/20 (2019.01); G16B 20/10 (2019.01); G16B 45/00 (2019.01)
CPC (source: EP KR US)
C07K 14/47 (2013.01 - EP KR); C12N 5/0637 (2013.01 - EP KR US); C12Q 1/6886 (2013.01 - EP KR); G16B 5/00 (2019.02 - EP KR US); G16B 5/20 (2019.02 - EP US); G16B 20/10 (2019.02 - EP US); C12Q 1/6886 (2013.01 - US); C12Q 2600/118 (2013.01 - EP KR US); C12Q 2600/156 (2013.01 - EP KR US); C12Q 2600/158 (2013.01 - EP KR US); C12Q 2600/178 (2013.01 - EP KR US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2018183363 A1 20181004; WO 2018183363 A4 20181108; AU 2018244307 A1 20191024; CA 3058382 A1 20181004; CN 110678928 A 20200110; EP 3601327 A1 20200205; IL 269729 A 20191128; JP 2020512004 A 20200423; KR 20190133038 A 20191129; SG 11201908880W A 20191030; US 2020051660 A1 20200213
DOCDB simple family (application)
US 2018024615 W 20180327; AU 2018244307 A 20180327; CA 3058382 A 20180327; CN 201880034462 A 20180327; EP 18778203 A 20180327; IL 26972919 A 20190926; JP 2019553967 A 20180327; KR 20197031916 A 20180327; SG 11201908880W A 20180327; US 201816498857 A 20180327