EP 3603669 A4 20210106 - AQUEOUS FORMULATION, AQUEOUS FORMULATION IN INJECTOR, ANTIBODY PROTEIN DISAGGREGATING AGENT, AND ANTIBODY PROTEIN DISAGGREGATION METHOD
Title (en)
AQUEOUS FORMULATION, AQUEOUS FORMULATION IN INJECTOR, ANTIBODY PROTEIN DISAGGREGATING AGENT, AND ANTIBODY PROTEIN DISAGGREGATION METHOD
Title (de)
WÄSSRIGE FORMULIERUNG, WÄSSRIGE FORMULIERUNG IN EINEM INJEKTOR, ANTIKÖRPERPROTEINDISAGGREGATIONSMITTEL UND ANTIKÖRPERPROTEINDISAGGREGATIONSVERFAHREN
Title (fr)
FORMULATION AQUEUSE, FORMULATION AQUEUSE DANS UN INJECTEUR, AGENT DE DÉSAGRÉGATION DE PROTÉINE D'ANTICORPS ET PROCÉDÉ DE DÉSAGRÉGATION DE PROTÉINE D'ANTICORPS
Publication
Application
Priority
- JP 2017070844 A 20170331
- JP 2018013559 W 20180330
Abstract (en)
[origin: EP3603669A1] An aqueous formulation comprises ustekinumab, at least one selected from histidine and salts thereof, and water, whereina content of the histidine and/or the salts thereof is 50 to 90 mM in terms of histidine.
IPC 8 full level
A61K 39/395 (2006.01); A61K 9/08 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61P 17/06 (2006.01); A61P 37/02 (2006.01)
CPC (source: EP KR US)
A61K 9/0019 (2013.01 - EP KR); A61K 9/08 (2013.01 - EP KR); A61K 39/39591 (2013.01 - EP KR US); A61K 47/183 (2013.01 - EP US); A61K 47/20 (2013.01 - KR); A61K 47/22 (2013.01 - KR); A61K 47/26 (2013.01 - EP KR US); A61P 17/06 (2018.01 - EP KR); A61P 37/02 (2018.01 - EP KR); C07K 16/244 (2013.01 - EP KR US); A61K 47/20 (2013.01 - US); A61K 47/22 (2013.01 - US); C07K 2317/21 (2013.01 - EP); C07K 2317/94 (2013.01 - EP)
Citation (search report)
- [Y] WO 2009114040 A2 20090917 - CENTOCOR ORTHO BIOTECH INC [US], et al
- [A] WO 2007076062 A2 20070705 - WYETH CORP [US], et al
- [Y] JANSSEN: "STELARA 45 mg Injektionslösung in einer Fertigspritze", 1 July 2011 (2011-07-01), pages 1 - 5, XP055467870, Retrieved from the Internet <URL:https://www.praxis-kiedrowski.de/files/fachinformation_stelara.pdf> [retrieved on 20180417]
- [Y] JACQUELINE M. BENSON ET AL: "Discovery and mechanism of ustekinumab: A human monoclonal antibody targeting interleukin-12 and interleukin-23 for treatment of immune-mediated disorders", MABS, vol. 3, no. 6, 1 November 2011 (2011-11-01), pages 535 - 545, XP055133436, ISSN: 1942-0862, DOI: 10.4161/mabs.3.6.17815
- [A] CHEN BEI ET AL: "Influence of histidine on the stability and physical properties of a fully human antibody in aqueous and solid forms", PHARMACEUTICAL RESEARCH, SPRINGER NEW YORK LLC, US, vol. 20, no. 12, 1 December 2003 (2003-12-01), pages 1952 - 1960, XP002386671, ISSN: 0724-8741, DOI: 10.1023/B:PHAM.0000008042.15988.C0
- [A] DING C ET AL: "ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseases", CURRENT OPINION IN INVESTIGATIONAL DRUGS, CURRENT DRUGS, LONDON, GB, vol. 9, no. 5, 1 January 2008 (2008-01-01), pages 515 - 522, XP008134761, ISSN: 0967-8298
- See also references of WO 2018181876A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3603669 A1 20200205; EP 3603669 A4 20210106; EP 3603669 B1 20240619; JP 7179717 B2 20221129; JP WO2018181876 A1 20200213; KR 20190129061 A 20191119; TW 201902461 A 20190116; TW I775827 B 20220901; US 2020093927 A1 20200326; WO 2018181876 A1 20181004
DOCDB simple family (application)
EP 18775644 A 20180330; JP 2018013559 W 20180330; JP 2019510230 A 20180330; KR 20197028836 A 20180330; TW 107111157 A 20180330; US 201816498633 A 20180330