EP 3612158 A4 20210127 - STIMULATION OF ANGIOGENESIS BY FIBROBLAST DERIVED EXOSOMES
Title (en)
STIMULATION OF ANGIOGENESIS BY FIBROBLAST DERIVED EXOSOMES
Title (de)
STIMULIERUNG DER ANGIOGENESE DURCH EXOSOMEN AUS FIBROBLASTEN
Title (fr)
STIMULATION DE L'ANGIOGENÈSE PAR DES EXOSOMES DÉRIVÉS DE FIBROBLASTES
Publication
Application
Priority
- US 201762487143 P 20170419
- US 2018028358 W 20180419
Abstract (en)
[origin: WO2018195308A1] Disclosed are methods, means, and compositions of matter useful for the stimulation of angiogenesis directly by administration of membrane vesicles, such as fibroblast-derived exosomes, and/or through induction of angiogenic cytokines from blood cells contacted with fibroblast-derived exosomes. The invention provides means of treating conditions in which angiogenesis is beneficial through local or systemic administration of exosomes, including those derived from fibroblasts, wherein the fibroblasts are cultured under basal conditions or conditions of hypoxia. In other embodiments exosomes derived from fibroblasts are utilized to augment endogenous regenerative processes, such as hematopoiesis, angiogenesis and neurogenesis, as well as augment regenerative processes stimulated by administration of exogenous therapeutics such as cells, growth factors, or genes.
IPC 8 full level
A61K 9/127 (2006.01); A61K 35/12 (2015.01); A61K 35/33 (2015.01); A61K 35/35 (2015.01); A61K 45/06 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61P 9/10 (2006.01)
CPC (source: EP US)
A61K 35/33 (2013.01 - EP US); A61L 27/3804 (2013.01 - EP); A61L 27/54 (2013.01 - EP); A61P 9/10 (2017.12 - EP); A61P 17/02 (2017.12 - US); C12N 5/0656 (2013.01 - US); A61K 9/1271 (2013.01 - EP); A61L 2300/414 (2013.01 - EP); C12N 2500/02 (2013.01 - US); C12N 2501/113 (2013.01 - US); C12N 2501/115 (2013.01 - US)
Citation (search report)
- [XI] WO 2015179227 A1 20151126 - CHILDRENS MEDICAL CENTER [US]
- [XI] US 2016243171 A1 20160825 - SHIELS PAUL [GB], et al
- [XI] WO 2016201323 A1 20161215 - UNIV TEXAS [US]
- [XI] WANG YINGJIE ET AL: "Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium", INTERNATIONAL JOURNAL OF CARDIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 192, 8 May 2015 (2015-05-08), pages 61 - 69, XP029174412, ISSN: 0167-5273, DOI: 10.1016/J.IJCARD.2015.05.020
- [A] YULIA SHAMIS ET AL: "Fibroblasts Derived from Human Pluripotent Stem Cells Activate Angiogenic Responses in Vitro and in Vivo", PLOS ONE, vol. 8, no. 12, 1 January 2013 (2013-01-01), pages e83755, XP055334708, DOI: 10.1371/journal.pone.0083755
- See references of WO 2018195308A1
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
WO 2018195308 A1 20181025; AU 2018254498 A1 20191010; AU 2018254498 B2 20230803; AU 2023216758 A1 20230907; CA 3058783 A1 20181025; CN 110520140 A 20191129; EP 3612158 A1 20200226; EP 3612158 A4 20210127; JP 2020517641 A 20200618; JP 2023099086 A 20230711; US 2020338133 A1 20201029
DOCDB simple family (application)
US 2018028358 W 20180419; AU 2018254498 A 20180419; AU 2023216758 A 20230815; CA 3058783 A 20180419; CN 201880025815 A 20180419; EP 18787206 A 20180419; JP 2019556899 A 20180419; JP 2023072818 A 20230427; US 201816495371 A 20180419