EP 3620159 A1 20200311 - THERAPEUTIC TREATMENT
Title (en)
THERAPEUTIC TREATMENT
Title (de)
THERAPEUTISCHE BEHANDLUNG
Title (fr)
TRAITEMENT THÉRAPEUTIQUE
Publication
Application
Priority
- US 201161470668 P 20110401
- EP 12715421 A 20120402
- GB 2012050736 W 20120402
Abstract (en)
The present invention relates to a combination comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide, or a pharmaceutically acceptable salt thereof, hereafter "Compound(I)", and a taxane. Taxanes include established cancer drugs such as docetaxel (Taxotere™) and paclitaxel (Taxol™). Such combinations may be useful in the treatment or prophylaxis of cancer. The invention also relates to a pharmaceutical composition comprising such Compound(I)and a taxane. The invention further relates to a method of treatment comprising the simultaneous, sequential or separate administration of Compound(I)and a taxane, to warm-blooded animal, such as man. The invention also relates to a kit comprising Compound(I)and a taxane, optionally with instructions for use.
IPC 8 full level
A61K 31/337 (2006.01); A61K 31/519 (2006.01); A61P 35/00 (2006.01)
CPC (source: EP KR US)
A61K 31/337 (2013.01 - EP KR US); A61K 31/519 (2013.01 - EP KR US); A61P 15/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
C-Set (source: EP US)
Citation (applicant)
- WO 2009047563 A1 20090416 - ASTRAZENECA AB [SE], et al
- US 5439686 A 19950808 - DESAI NEIL P [US], et al
- US 6749868 B1 20040615 - DESAI NEIL P [US], et al
- US 2008161382 A1 20080703 - DESAI NEIL [US], et al
- US 2007117744 A1 20070524 - DESAI NEIL P [US], et al
- US 2007082838 A1 20070412 - DE TAPAS [US], et al
- US 6645528 B1 20031111 - STRAUB JULIE [US], et al
- LI C.: "Poly ( L -glutamic acid) - anticancer drug conjugates", ADV. DRUG DELIV. REV., vol. 54, 2002, pages 695 - 713, XP001199485, doi:10.1016/S0169-409X(02)00045-5
- BRADLEY MO ET AL.: "Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel", CLIN. CANCER RES., vol. 7, 2001, pages 3229 - 38, XP002272095
Citation (search report)
- [Y] WO 2009047563 A1 20090416 - ASTRAZENECA AB [SE], et al
- [Y] US 2004014694 A1 20040122 - CHAKROUN HICHEM [FR]
- [Y] WO 02076484 A2 20021003 - AVENTIS PHARMA SA [FR]
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2012131399 A1 20121004; AU 2012235902 A1 20130502; AU 2012235902 B2 20150827; BR 112013025410 A2 20161220; CA 2831848 A1 20121004; CA 2831848 C 20201222; CN 103442708 A 20131211; CN 103442708 B 20161109; CY 1122608 T1 20210312; DK 2694056 T3 20200102; EA 027506 B1 20170831; EA 201391327 A1 20140331; EP 2694056 A1 20140212; EP 2694056 B1 20191016; EP 3620159 A1 20200311; ES 2761311 T3 20200519; HR P20191927 T1 20200110; HU E047357 T2 20200428; IL 228589 A0 20131231; IL 228589 B 20190926; JP 2014509639 A 20140421; JP 6080837 B2 20170215; KR 101851820 B1 20180604; KR 20140022856 A 20140225; LT 2694056 T 20191210; ME 03589 B 20200720; MX 2013011413 A 20140521; MX 357447 B 20180710; MY 169449 A 20190411; NZ 616410 A 20150925; PL 2694056 T3 20200331; PT 2694056 T 20191120; RS 59568 B1 20191231; SG 193505 A1 20131030; SI 2694056 T1 20191231; US 2014121227 A1 20140501; US 2016317540 A1 20161103; US 9402847 B2 20160802; ZA 201308176 B 20151223
DOCDB simple family (application)
GB 2012050736 W 20120402; AU 2012235902 A 20120402; BR 112013025410 A 20120402; CA 2831848 A 20120402; CN 201280016297 A 20120402; CY 191101325 T 20191217; DK 12715421 T 20120402; EA 201391327 A 20120402; EP 12715421 A 20120402; EP 19199392 A 20120402; ES 12715421 T 20120402; HR P20191927 T 20191023; HU E12715421 A 20120402; IL 22858913 A 20130929; JP 2014501727 A 20120402; KR 20137028772 A 20120402; LT 12715421 T 20120402; ME P2019344 A 20120402; MX 2013011413 A 20120402; MY PI2013701819 A 20120402; NZ 61641012 A 20120402; PL 12715421 T 20120402; PT 12715421 T 20120402; RS P20191518 A 20120402; SG 2013069943 A 20120402; SI 201231689 T 20120402; US 201214008459 A 20120402; US 201615205218 A 20160708; ZA 201308176 A 20131031