EP 3624834 A1 20200325 - TRANSGENIC MACROPHAGES, CHIMERIC ANTIGEN RECEPTORS, AND ASSOCIATED METHODS
Title (en)
TRANSGENIC MACROPHAGES, CHIMERIC ANTIGEN RECEPTORS, AND ASSOCIATED METHODS
Title (de)
TRANSGENE MAKROPHAGEN, CHIMÄRE ANTIGENREZEPTOREN UND ZUGEHÖRIGE VERFAHREN
Title (fr)
MACROPHAGES TRANSGÉNIQUES, RÉCEPTEURS D'ANTIGÈNES CHIMÉRIQUES ET MÉTHODES ASSOCIÉES
Publication
Application
Priority
US 2017033039 W 20170517
Abstract (en)
[origin: WO2018212770A1] Described herein are chimeric receptors. Chimeric receptors comprise a cytoplasmic domain; a transmembrane domain; and an extracellular domain. In embodiments, the cytoplasmic domain comprises a cyptoplasmic portion of a receptor that when activated polarizes a macrophage. In further embodiments, a wild-type protein comprising the cytoplasmic portion does not comprise the extracellular domain of the chimeric receptor. In embodiments, the binding of a ligand to the extracellular domain of the chimeric receptor activates the intracellular portion of the chimeric receptor. Activation of the intracellular portion of the chimeric receptor may polarize the macrophage into an M1 or M2 macrophage.
IPC 8 full level
A61K 39/00 (2006.01); A61K 35/15 (2015.01); C07K 16/40 (2006.01)
CPC (source: EP KR)
A61K 39/001162 (2018.08 - KR); A61K 39/4614 (2023.05 - EP); A61K 39/4622 (2023.05 - EP); A61K 39/4631 (2023.05 - EP); A61K 39/464404 (2023.05 - EP); A61K 39/464406 (2023.05 - EP); A61K 39/464417 (2023.05 - EP); A61K 39/464422 (2023.05 - EP); A61K 39/464454 (2023.05 - EP); A61K 39/464462 (2023.05 - EP); A61K 39/464468 (2023.05 - EP); A61K 39/46447 (2023.05 - EP); A61K 39/464471 (2023.05 - EP); A61K 39/464482 (2023.05 - EP); A61P 35/00 (2018.01 - EP KR); C07K 16/30 (2013.01 - EP KR); C07K 16/40 (2013.01 - EP KR); A61K 38/00 (2013.01 - EP); A61K 2039/5154 (2013.01 - KR); A61K 2039/5156 (2013.01 - KR); A61K 2039/5158 (2013.01 - KR); A61K 2239/13 (2023.05 - EP); A61K 2239/21 (2023.05 - EP); A61K 2239/55 (2023.05 - EP); C07K 2317/622 (2013.01 - EP KR); C07K 2319/03 (2013.01 - EP KR)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
WO 2018212770 A1 20181122; AU 2017414703 A1 20200116; CA 3062978 A1 20181122; CN 110662553 A 20200107; EP 3624834 A1 20200325; JP 2020520252 A 20200709; JP 2022189893 A 20221222; JP 7164598 B2 20221101; KR 102508182 B1 20230309; KR 20200020708 A 20200226; ZA 201908245 B 20201223
DOCDB simple family (application)
US 2017033039 W 20170517; AU 2017414703 A 20170517; CA 3062978 A 20170517; CN 201780090935 A 20170517; EP 17731332 A 20170517; JP 2020514655 A 20170517; JP 2022167762 A 20221019; KR 20197037141 A 20170517; ZA 201908245 A 20191211