Global Patent Index - EP 3624849 A4

EP 3624849 A4 20210224 - COMBINATION THERAPY USING ASCOCHLORIN DERIVATIVE

Title (en)

COMBINATION THERAPY USING ASCOCHLORIN DERIVATIVE

Title (de)

KOMBINATIONSTHERAPIE MIT ASCOCHLORINDERIVAT

Title (fr)

POLYTHÉRAPIE UTILISANT UN DÉRIVÉ D'ASCOCHLORINE

Publication

EP 3624849 A4 20210224 (EN)

Application

EP 18802154 A 20180518

Priority

  • JP 2017098860 A 20170518
  • JP 2018020087 W 20180518

Abstract (en)

[origin: WO2018212363A1] An object of the present invention is to provide a measure for treating or preventing a disease or condition that involves AMPK dysregulation, particularly a cancer. The present invention provides a combination therapy using a compound presented by formula (I), a pharmaceutically acceptable salt or a solvate thereof with an immune checkpoint inhibitor.

IPC 8 full level

A61K 45/00 (2006.01); A61K 31/055 (2006.01); A61K 31/155 (2006.01); A61K 39/395 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 16/28 (2006.01)

CPC (source: EP US)

A61K 31/055 (2013.01 - EP US); A61K 31/122 (2013.01 - US); A61K 31/15 (2013.01 - US); A61K 31/215 (2013.01 - US); A61K 31/337 (2013.01 - US); A61K 31/495 (2013.01 - US); A61K 31/5375 (2013.01 - US); A61K 39/3955 (2013.01 - EP); A61K 45/06 (2013.01 - EP); A61P 35/00 (2018.01 - EP US); C07K 16/2818 (2013.01 - EP US); C07K 16/2827 (2013.01 - US); A61K 31/155 (2013.01 - EP); C07K 2317/76 (2013.01 - EP)

C-Set (source: EP)

A61K 39/3955 + A61K 2300/00

Citation (search report)

  • [XP] WO 2017119515 A1 20170713 - NRL PHARMA INC [JP]
  • [A] JI-HAK JEONG ET AL: "4--methylascochlorin, methylated derivative of ascochlorin, stabilizes HIF-1 via AMPK activation", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 406, no. 3, 15 February 2011 (2011-02-15), pages 353 - 358, XP028166930, ISSN: 0006-291X, [retrieved on 20110215], DOI: 10.1016/J.BBRC.2011.02.043
  • [A] W. M. ANOJA P. WANIGESEKARA ET AL: "10'-Deoxy-10' [alpha]-hydroxyascochlorin, a New Cell Migration Inhibitor and Other Metabolites from Acremonium sp., a Fungal Endophyte in Ephedra trifurca", NATURAL PRODUCT COMMUNICATIONS, vol. 8, no. 5, 1 May 2013 (2013-05-01), US, pages 601 - 604, XP055616303, ISSN: 1934-578X, DOI: 10.1177/1934578X1300800515
  • [A] SHIN JAE-MOON ET AL: "Suppression of c-Myc induces apoptosis via an AMPK/mTOR-dependent pathway by 4-O-methyl-ascochlorin in leukemia cells", APOPTOSIS, LONDON, GB, vol. 21, no. 5, 27 February 2016 (2016-02-27), pages 657 - 668, XP035899813, ISSN: 1360-8185, [retrieved on 20160227], DOI: 10.1007/S10495-016-1228-3
  • [A] PARK JUNSIK ET AL: "Immune checkpoint inhibitors for cancer treatment", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 39, no. 11, 21 October 2016 (2016-10-21), pages 1577 - 1587, XP036106757, ISSN: 0253-6269, [retrieved on 20161021], DOI: 10.1007/S12272-016-0850-5
  • See also references of WO 2018212363A1

Designated contracting state (EPC)

AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DOCDB simple family (publication)

WO 2018212363 A1 20181122; CN 110636860 A 20191231; CN 110636860 B 20220301; EP 3624849 A1 20200325; EP 3624849 A4 20210224; JP 2020520378 A 20200709; JP 7102006 B2 20220719; US 11298358 B2 20220412; US 2021346390 A1 20211111

DOCDB simple family (application)

JP 2018020087 W 20180518; CN 201880032981 A 20180518; EP 18802154 A 20180518; JP 2019563912 A 20180518; US 201816613958 A 20180518