EP 3636642 A4 20210324 - INDOLEACETIC ACID DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
Title (en)
INDOLEACETIC ACID DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
Title (de)
INDOLESSIGSÄUREDERIVAT UND HERSTELLUNGSVERFAHREN SOWIE PHARMAZEUTISCHE VERWENDUNG DAVON
Title (fr)
DÉRIVÉ D'ACIDE INDOLACÉTIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION PHARMACEUTIQUE
Publication
Application
Priority
- CN 201710421776 A 20170607
- CN 2018086774 W 20180515
Abstract (en)
[origin: EP3636642A1] The present invention relates to an indoleacetic acid derivative and a preparation method and pharmaceutical use thereof. In particular, the present invention relates to a compound shown in general formula (I), a preparation method thereof, a pharmaceutical composition comprising the same, and a use thereof as a cough suppressant in treating a disease such as a cough. The definition of each substituent in the general formula (I) is the same as the definition in the specification.
IPC 8 full level
A61K 31/7056 (2006.01); A61P 11/06 (2006.01); A61P 11/08 (2006.01); A61P 11/14 (2006.01); C07H 1/00 (2006.01); C07H 19/02 (2006.01)
CPC (source: EP US)
A61K 31/7056 (2013.01 - EP); A61P 11/06 (2017.12 - EP); A61P 11/08 (2017.12 - EP); A61P 11/14 (2017.12 - EP); C07D 405/04 (2013.01 - EP); C07H 1/00 (2013.01 - EP); C07H 19/02 (2013.01 - EP); C07H 19/044 (2013.01 - US)
Citation (search report)
- [XA] KAI ET AL: "Metabolism of indole-3-acetic acid in rice: Identification and characterization of N-@b-d-glucopyranosyl indole-3-acetic acid and its conjugates", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM , NL, vol. 68, no. 20, 26 September 2007 (2007-09-26), pages 2512 - 2522, XP022273987, ISSN: 0031-9422, DOI: 10.1016/J.PHYTOCHEM.2007.05.040
- [XA] LJUNG KARIN ET AL: "Developmental Regulation of Indole-3-Acetic Acid Turnover in Scots Pine Seedlings", PLANT PHYSIOLOGY, vol. 125, no. 1, 1 January 2001 (2001-01-01), Rockville, Md, USA, pages 464 - 475, XP055774961, ISSN: 0032-0889, DOI: 10.1104/pp.125.1.464
- [A] TAN MIN-JIA ET AL: "Antitussive Indole Alkaloids from Kopsia hainanensis", PLANTA MEDICA, vol. 77, no. 09, 16 December 2010 (2010-12-16), DE, pages 939 - 944, XP055775337, ISSN: 0032-0943, Retrieved from the Internet <URL:https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0030-1250631.pdf> DOI: 10.1055/s-0030-1250631
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
DOCDB simple family (publication)
EP 3636642 A1 20200415; EP 3636642 A4 20210324; EP 3636642 A8 20200701; CN 110418787 A 20191105; CN 110418787 B 20220913; JP 2020522579 A 20200730; JP 7152479 B2 20221012; US 11008360 B2 20210518; US 2020095271 A1 20200326; WO 2018223819 A1 20181213
DOCDB simple family (application)
EP 18813675 A 20180515; CN 2018086774 W 20180515; CN 201880016571 A 20180515; JP 2020518115 A 20180515; US 201816620015 A 20180515