EP 3636655 A1 20200415 - CRYSTAL FORM OF FATTY ACID BILE ACID CONJUGATE, METHOD FOR PREPARING SAME, AND APPLICATION
Title (en)
CRYSTAL FORM OF FATTY ACID BILE ACID CONJUGATE, METHOD FOR PREPARING SAME, AND APPLICATION
Title (de)
KRISTALLFORM EINES FETTSÄURE-GALLENSÄURE-KONJUGATS, HERSTELLUNGSVERFAHREN DAFÜR UND ANWENDUNG
Title (fr)
FORME CRISTALLINE D'UN CONJUGUÉ ACIDE GRAS - ACIDE BILIAIRE, SON PROCÉDÉ DE PRÉPARATION ET APPLICATION
Publication
Application
Priority
- CN 201710423951 A 20170607
- CN 2018087680 W 20180521
Abstract (en)
The present disclosure relates to novel crystalline forms of compound (I) and processes for preparation and use thereof. Crystalline forms CS3, CS2, CS5 and CS8 of compound (I) of the present disclosure have advantages in at least one aspect of solubility, stability, melting point, hygroscopicity, particle size, bioavailability, processability, purification effect, flowability, adhesiveness, stability in drug product, in vitro and in vivo dissolution, etc., which provides new and better choices for preparation of drug product containing compound (I) and has significant values for future drug development.
IPC 8 full level
A61K 31/575 (2006.01); A61P 1/04 (2006.01); C07C 229/26 (2006.01); C07J 9/00 (2006.01); C07J 41/00 (2006.01)
CPC (source: EP US)
A61K 31/575 (2013.01 - EP); A61P 1/04 (2017.12 - EP US); A61P 9/10 (2017.12 - US); C07J 41/0005 (2013.01 - EP US); C07B 2200/13 (2013.01 - EP US)
Designated contracting state (EPC)
AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
Designated extension state (EPC)
BA ME
DOCDB simple family (publication)
EP 3636655 A1 20200415; EP 3636655 A4 20200826; CN 110730785 A 20200124; CN 110730785 B 20220517; US 11136347 B2 20211005; US 2021147471 A1 20210520; WO 2018223836 A1 20181213
DOCDB simple family (application)
EP 18812950 A 20180521; CN 2018087680 W 20180521; CN 201880035796 A 20180521; US 201816620115 A 20180521